The mechanistic basis for psoriasis immunopathogenesis: Translating genotype to phenotype. Report of a workshop, Venice, 2012

H. Bachelez, M. Viguier, P. W. Tebbey, M. Lowes, M. Suárez-Fariñas, A. Costanzo, F. O. Nestle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The International Psoriasis Council, a global nonprofit organization dedicated to advancing psoriasis research and treatment, led an initiative to better define the pathogenic mechanisms that constitute psoriasis. In September 2012, a workshop was held at the 42nd Annual European Society for Dermatological Research in Venice, Italy. By assembling a panel of global dermatology and immunology experts, the objective was to evaluate the current status of the science explaining the mechanism of disease in psoriasis, e.g. dysregulation of the skin immune system and perturbations of epidermal homeostasis. The workshop consisted of four oral presentations, which addressed key topics in psoriasis, delivered by Hervé Bachelez (Paris, France), Antonio Costanzo (Rome, Italy), Michelle Lowes (New York, NY, U.S.A.) and Frank Nestle (London, U.K.). A global expert panel was assembled to stimulate dialogue and debate: Kevin Cooper (Cleveland, OH, U.S.A.), Michel Gilliet (Lausanne, Switzerland), Joerg Prinz (Munich, Germany), Martin Röcken (Tubingen, Germany), Jens Schroeder (Kiel, Germany), Manuelle Viguier (Paris, France), Mayte Suárez- Fariñas (New York, NY, U.S.A.) and Cristina Zielinski (Berlin, Germany). Collectively, the presentations demonstrated the significant advances in understanding immune regulation that have occurred over the past decade by virtue of the study of psoriasis subtypes, phenotypic manifestations and genetic associations. Elucidating the pathogenic and genetic basis of psoriasis holds the promise of a complete understanding of disease mechanisms, predictors of treatment response, novel drug development strategies and customized therapeutic regimens for the individual patient.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalBritish Journal of Dermatology
Volume169
Issue number2
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint

Psoriasis
Genotype
Phenotype
Education
Germany
Paris
Italy
France
Nonprofit Organizations
Berlin
Dermatology
Allergy and Immunology
Switzerland
Immune System
Homeostasis
Skin
Therapeutics
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dermatology

Cite this

Bachelez, H., Viguier, M., Tebbey, P. W., Lowes, M., Suárez-Fariñas, M., Costanzo, A., & Nestle, F. O. (2013). The mechanistic basis for psoriasis immunopathogenesis: Translating genotype to phenotype. Report of a workshop, Venice, 2012. British Journal of Dermatology, 169(2), 283-286. https://doi.org/10.1111/bjd.12347

The mechanistic basis for psoriasis immunopathogenesis : Translating genotype to phenotype. Report of a workshop, Venice, 2012. / Bachelez, H.; Viguier, M.; Tebbey, P. W.; Lowes, M.; Suárez-Fariñas, M.; Costanzo, A.; Nestle, F. O.

In: British Journal of Dermatology, Vol. 169, No. 2, 08.2013, p. 283-286.

Research output: Contribution to journalArticle

Bachelez, H, Viguier, M, Tebbey, PW, Lowes, M, Suárez-Fariñas, M, Costanzo, A & Nestle, FO 2013, 'The mechanistic basis for psoriasis immunopathogenesis: Translating genotype to phenotype. Report of a workshop, Venice, 2012', British Journal of Dermatology, vol. 169, no. 2, pp. 283-286. https://doi.org/10.1111/bjd.12347
Bachelez, H. ; Viguier, M. ; Tebbey, P. W. ; Lowes, M. ; Suárez-Fariñas, M. ; Costanzo, A. ; Nestle, F. O. / The mechanistic basis for psoriasis immunopathogenesis : Translating genotype to phenotype. Report of a workshop, Venice, 2012. In: British Journal of Dermatology. 2013 ; Vol. 169, No. 2. pp. 283-286.
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