The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine

Paolo Bianco, Xu Cao, Paul S. Frenette, Jeremy J. Mao, Pamela G. Robey, Paul J. Simmons, Cun Yu Wang

Research output: Contribution to journalReview article

718 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalNature Medicine
Volume19
Issue number1
DOIs
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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