The mast cell: A potential therapeutic target in myocardial infarction

Pawel Zymek, Porur Somasundaram, Anna Cieslak, Nikolaos G. Frangogiannis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mast cells are multifunctional effector cells of the immune system, capable of producing a variety of vasoactive mediators, cytokines and growth factors. The presence of resident mast cells in the myocardium has been established; however, their exact role in cardiac pathology remains unclear. The current review presents evidence suggesting the importance of mast cells in the infarcted myocardium. Myocardial ischemia and reperfusion results in degranulation of cardiac mast cells, and release of preformed inflammatory mediators, such as TNF-α and histamine in the ischemic area. Mast cell derived products may modulate endothelial gene expression and mononuclear cell cytokine synthesis. During the proliferative phase of healing, significant mast cell accumulation is noted in areas of fibrosis and myofibroblast proliferation. Stem Cell Factor (SCF), the obligate growth factor for mast cells, is induced in the healing myocardium. Mast cells may have an important role in scar formation through the secretion of growth factors and fibrogenic substances (such as TGF-β, basic FGF, tryptase and VEGF), that may promote collagen deposition and angiogenesis. Understanding the role of the mast cell in myocardial infarction is important in order to design site-specific pharmacological interventions that could mitigate inflammatory injury, without interfering with myocardial healing.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalDrug Design Reviews Online
Volume2
Issue number3
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Mast Cells
Myocardial Infarction
Myocardium
Stem Cell Factor
Therapeutics
Intercellular Signaling Peptides and Proteins
Cytokines
Tryptases
Myocardial Reperfusion
Myofibroblasts
Histamine
Vascular Endothelial Growth Factor A
Cicatrix
Myocardial Ischemia
Immune System
Fibrosis
Collagen
Pharmacology
Pathology
Gene Expression

Keywords

  • Chemokine
  • Cytokine
  • Growth factor
  • Infarction
  • Inflammation
  • Mast cell

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

Cite this

The mast cell : A potential therapeutic target in myocardial infarction. / Zymek, Pawel; Somasundaram, Porur; Cieslak, Anna; Frangogiannis, Nikolaos G.

In: Drug Design Reviews Online, Vol. 2, No. 3, 05.2005, p. 219-225.

Research output: Contribution to journalArticle

Zymek, Pawel ; Somasundaram, Porur ; Cieslak, Anna ; Frangogiannis, Nikolaos G. / The mast cell : A potential therapeutic target in myocardial infarction. In: Drug Design Reviews Online. 2005 ; Vol. 2, No. 3. pp. 219-225.
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