The mammary gland iodide transporter is expressed during lactation and in breast cancer

Uygar H. Tazebay, Irene L. Wapnir, Orlie Levy, Orsolya Dohan, Lionel S. Zuckier, Qing Hua Zhao, Hou Fu Deng, Peter S. Amenta, Susan A. Fineberg, Richard G. Pestell, Nancy Carrasco

Research output: Contribution to journalArticle

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Abstract

The sodium/iodide symporter mediates active iodide transport in both healthy and cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades with considerable success in the detection and treatment of thyroid cancer. Here we show that a specialized form of the sodium/iodide symporter in the mammary gland mediates active iodide transport in healthy lactating (but not in nonlactating) mammary gland and in mammary tumors. In addition to characterizing the hormonal regulation of the mammary gland sodium/iodide symporter, we demonstrate by scintigraphy that mammary adenocarcinomas in transgenic mice bearing Ras or Neu oncogenes actively accumulate iodide by this symporter in vivo. Moreover, more than 80% of the human breast cancer samples we analyzed by immunohistochemistry expressed the symporter, compared with none of the normal (nonlactating) samples from reductive mammoplasties. These results indicate that the mammary gland sodium/iodide symporter may be an essential breast cancer marker and that radioiodide should be studied as a possible option in the diagnosis and treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)871-878
Number of pages8
JournalNature Medicine
Volume6
Issue number8
DOIs
StatePublished - Aug 2000

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Iodides
Human Mammary Glands
Lactation
Breast Neoplasms
Symporters
Active Biological Transport
Bearings (structural)
Mammaplasty
Oncogenes
Thyroid Neoplasms
Radionuclide Imaging
Transgenic Mice
Tumors
Thyroid Gland
Adenocarcinoma
Breast
Immunohistochemistry
Tissue
sodium-iodide symporter
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tazebay, U. H., Wapnir, I. L., Levy, O., Dohan, O., Zuckier, L. S., Zhao, Q. H., ... Carrasco, N. (2000). The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nature Medicine, 6(8), 871-878. https://doi.org/10.1038/78630

The mammary gland iodide transporter is expressed during lactation and in breast cancer. / Tazebay, Uygar H.; Wapnir, Irene L.; Levy, Orlie; Dohan, Orsolya; Zuckier, Lionel S.; Zhao, Qing Hua; Deng, Hou Fu; Amenta, Peter S.; Fineberg, Susan A.; Pestell, Richard G.; Carrasco, Nancy.

In: Nature Medicine, Vol. 6, No. 8, 08.2000, p. 871-878.

Research output: Contribution to journalArticle

Tazebay, UH, Wapnir, IL, Levy, O, Dohan, O, Zuckier, LS, Zhao, QH, Deng, HF, Amenta, PS, Fineberg, SA, Pestell, RG & Carrasco, N 2000, 'The mammary gland iodide transporter is expressed during lactation and in breast cancer', Nature Medicine, vol. 6, no. 8, pp. 871-878. https://doi.org/10.1038/78630
Tazebay, Uygar H. ; Wapnir, Irene L. ; Levy, Orlie ; Dohan, Orsolya ; Zuckier, Lionel S. ; Zhao, Qing Hua ; Deng, Hou Fu ; Amenta, Peter S. ; Fineberg, Susan A. ; Pestell, Richard G. ; Carrasco, Nancy. / The mammary gland iodide transporter is expressed during lactation and in breast cancer. In: Nature Medicine. 2000 ; Vol. 6, No. 8. pp. 871-878.
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