The lymph self-antigen repertoire

Cristina C. Clement, Laura Santambrogio

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the "omic" composition of the tissue from which it originates in its physiological or pathological signature. Several recent proteomic analyses have mapped the proteome-degradome and peptidome of this immunologically relevant fluid pointing to the lymph as an important source of tissue-derived self-antigens. A vast array of lymph-circulating peptides have been mapped deriving from a variety of processing pathways including caspases, cathepsins, MMPs, ADAMs, kallikreins, calpains, and granzymes, among others. These self peptides can be directly loaded on circulatory dendritic cells and expand the self-antigenic repertoire available for central and peripheral tolerance.

Original languageEnglish (US)
Article numberArticle 424
JournalFrontiers in Immunology
Volume4
Issue numberDEC
DOIs
StatePublished - 2013

Fingerprint

Autoantigens
Lymph
Central Tolerance
Peripheral Tolerance
Cathepsins
Granzymes
Peptides
Kallikreins
Calpain
Extracellular Fluid
Proteome
Caspases
Matrix Metalloproteinases
Proteomics
Dendritic Cells

Keywords

  • Antigen presentation
  • Antigen processing
  • Lymph
  • MHC class II

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The lymph self-antigen repertoire. / Clement, Cristina C.; Santambrogio, Laura.

In: Frontiers in Immunology, Vol. 4, No. DEC, Article 424, 2013.

Research output: Contribution to journalArticle

Clement, Cristina C. ; Santambrogio, Laura. / The lymph self-antigen repertoire. In: Frontiers in Immunology. 2013 ; Vol. 4, No. DEC.
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