The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals

Manasi Agrawal, Olga C. Aroniadis, Lawrence J. Brandt, Colleen Kelly, Sarah Freeman, Christina Surawicz, Elizabeth Broussard, Neil Stollman, Andrea Giovanelli, Becky Smith, Eugene Yen, Apurva Trivedi, Levi Hubble, Dina Kao, Thomas Borody, Sarah Finlayson, Arnab Ray, Robert Smith

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

OBJECTIVES:: Clostridium difficile infection (CDI) in the elderly has a higher prevalence, greater morbidity and mortality, and lower response to conventional treatment than the general population. Fecal microbiota transplant (FMT) is highly effective therapy for CDI but has not been studied specifically in the elderly. This study aims to determine the long-term efficacy and safety of FMT for recurrent (RCDI), severe (SCDI), and complicated (CCDI) CDI in elderly patients. METHODS:: A multicenter, long-term follow-up study was performed with demographic, pre-FMT, and post-FMT data collected from elderly patients with RCDI, SCDI, and CCDI, through a 47-item questionnaire. Outcome measures included primary and secondary cure rates, early (

Original languageEnglish (US)
JournalJournal of Clinical Gastroenterology
DOIs
StateAccepted/In press - Aug 26 2015

    Fingerprint

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Agrawal, M., Aroniadis, O. C., Brandt, L. J., Kelly, C., Freeman, S., Surawicz, C., Broussard, E., Stollman, N., Giovanelli, A., Smith, B., Yen, E., Trivedi, A., Hubble, L., Kao, D., Borody, T., Finlayson, S., Ray, A., & Smith, R. (Accepted/In press). The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals. Journal of Clinical Gastroenterology. https://doi.org/10.1097/MCG.0000000000000410