The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals

Manasi Agrawal, Olga C. Aroniadis, Lawrence J. Brandt, Colleen Kelly, Sarah Freeman, Christina Surawicz, Elizabeth Broussard, Neil Stollman, Andrea Giovanelli, Becky Smith, Eugene Yen, Apurva Trivedi, Levi Hubble, Dina Kao, Thomas Borody, Sarah Finlayson, Arnab Ray, Robert Smith

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

OBJECTIVES:: Clostridium difficile infection (CDI) in the elderly has a higher prevalence, greater morbidity and mortality, and lower response to conventional treatment than the general population. Fecal microbiota transplant (FMT) is highly effective therapy for CDI but has not been studied specifically in the elderly. This study aims to determine the long-term efficacy and safety of FMT for recurrent (RCDI), severe (SCDI), and complicated (CCDI) CDI in elderly patients. METHODS:: A multicenter, long-term follow-up study was performed with demographic, pre-FMT, and post-FMT data collected from elderly patients with RCDI, SCDI, and CCDI, through a 47-item questionnaire. Outcome measures included primary and secondary cure rates, early (

Original languageEnglish (US)
JournalJournal of Clinical Gastroenterology
DOIs
StateAccepted/In press - Aug 26 2015

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Clostridium Infections
Clostridium difficile
Microbiota
Safety
Demography
Outcome Assessment (Health Care)
Morbidity
Mortality
Fecal Microbiota Transplantation
Therapeutics
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals. / Agrawal, Manasi; Aroniadis, Olga C.; Brandt, Lawrence J.; Kelly, Colleen; Freeman, Sarah; Surawicz, Christina; Broussard, Elizabeth; Stollman, Neil; Giovanelli, Andrea; Smith, Becky; Yen, Eugene; Trivedi, Apurva; Hubble, Levi; Kao, Dina; Borody, Thomas; Finlayson, Sarah; Ray, Arnab; Smith, Robert.

In: Journal of Clinical Gastroenterology, 26.08.2015.

Research output: Contribution to journalArticle

Agrawal, M, Aroniadis, OC, Brandt, LJ, Kelly, C, Freeman, S, Surawicz, C, Broussard, E, Stollman, N, Giovanelli, A, Smith, B, Yen, E, Trivedi, A, Hubble, L, Kao, D, Borody, T, Finlayson, S, Ray, A & Smith, R 2015, 'The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals', Journal of Clinical Gastroenterology. https://doi.org/10.1097/MCG.0000000000000410
Agrawal, Manasi ; Aroniadis, Olga C. ; Brandt, Lawrence J. ; Kelly, Colleen ; Freeman, Sarah ; Surawicz, Christina ; Broussard, Elizabeth ; Stollman, Neil ; Giovanelli, Andrea ; Smith, Becky ; Yen, Eugene ; Trivedi, Apurva ; Hubble, Levi ; Kao, Dina ; Borody, Thomas ; Finlayson, Sarah ; Ray, Arnab ; Smith, Robert. / The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals. In: Journal of Clinical Gastroenterology. 2015.
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AU - Aroniadis, Olga C.

AU - Brandt, Lawrence J.

AU - Kelly, Colleen

AU - Freeman, Sarah

AU - Surawicz, Christina

AU - Broussard, Elizabeth

AU - Stollman, Neil

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AU - Yen, Eugene

AU - Trivedi, Apurva

AU - Hubble, Levi

AU - Kao, Dina

AU - Borody, Thomas

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AU - Ray, Arnab

AU - Smith, Robert

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AB - OBJECTIVES:: Clostridium difficile infection (CDI) in the elderly has a higher prevalence, greater morbidity and mortality, and lower response to conventional treatment than the general population. Fecal microbiota transplant (FMT) is highly effective therapy for CDI but has not been studied specifically in the elderly. This study aims to determine the long-term efficacy and safety of FMT for recurrent (RCDI), severe (SCDI), and complicated (CCDI) CDI in elderly patients. METHODS:: A multicenter, long-term follow-up study was performed with demographic, pre-FMT, and post-FMT data collected from elderly patients with RCDI, SCDI, and CCDI, through a 47-item questionnaire. Outcome measures included primary and secondary cure rates, early (

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