The location of C2, C4, and BF relative to HLA-B and HLA-D

Donald Douglas Raum, Zuheir L. Awdeh, David Glass, Edmond Yunis, Chester A. Alper

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The loci for HLA-A, B, C, D, and DR are known to be closely linked to the structural loci for the complement components C2, BF, and the duplicated loci for C4, C4A and C4B. Conflicting evidence has been presented for the order of these genes. However, new techniques have made possible identification of markers in the HLA-D and C4 region for nearly all identified haplotypes. In our population we have confirmed five HLA-B-D crossovers and in each case informative allotypes of C2, BF, or C4A and C4B segregated with HLA-D or DR suggesting that the loci for these proteins lie close to HLA-D and DR. These findings may be of importance for resolving problems encountered in the assignment of HLA-D alleles.

Original languageEnglish (US)
Pages (from-to)473-483
Number of pages11
JournalImmunogenetics
Volume12
Issue number1
DOIs
StatePublished - Dec 1981
Externally publishedYes

Fingerprint

HLA-D Antigens
HLA-B Antigens
HLA-DR Antigens
Complement C2
Gene Order
HLA-A Antigens
Haplotypes
Alleles
Population
Proteins

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Raum, D. D., Awdeh, Z. L., Glass, D., Yunis, E., & Alper, C. A. (1981). The location of C2, C4, and BF relative to HLA-B and HLA-D. Immunogenetics, 12(1), 473-483. https://doi.org/10.1007/BF01561689

The location of C2, C4, and BF relative to HLA-B and HLA-D. / Raum, Donald Douglas; Awdeh, Zuheir L.; Glass, David; Yunis, Edmond; Alper, Chester A.

In: Immunogenetics, Vol. 12, No. 1, 12.1981, p. 473-483.

Research output: Contribution to journalArticle

Raum, DD, Awdeh, ZL, Glass, D, Yunis, E & Alper, CA 1981, 'The location of C2, C4, and BF relative to HLA-B and HLA-D', Immunogenetics, vol. 12, no. 1, pp. 473-483. https://doi.org/10.1007/BF01561689
Raum, Donald Douglas ; Awdeh, Zuheir L. ; Glass, David ; Yunis, Edmond ; Alper, Chester A. / The location of C2, C4, and BF relative to HLA-B and HLA-D. In: Immunogenetics. 1981 ; Vol. 12, No. 1. pp. 473-483.
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