The location of C2, C4, and BF relative to HLA-B and HLA-D

Donald D. Raum, Zuheir L. Awdeh, David Glass, Edmond Yunis, Chester A. Alper

Research output: Contribution to journalArticle

26 Scopus citations


The loci for HLA-A, B, C, D, and DR are known to be closely linked to the structural loci for the complement components C2, BF, and the duplicated loci for C4, C4A and C4B. Conflicting evidence has been presented for the order of these genes. However, new techniques have made possible identification of markers in the HLA-D and C4 region for nearly all identified haplotypes. In our population we have confirmed five HLA-B-D crossovers and in each case informative allotypes of C2, BF, or C4A and C4B segregated with HLA-D or DR suggesting that the loci for these proteins lie close to HLA-D and DR. These findings may be of importance for resolving problems encountered in the assignment of HLA-D alleles.

Original languageEnglish (US)
Pages (from-to)473-483
Number of pages11
Issue number1
Publication statusPublished - Dec 1 1981
Externally publishedYes


ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Raum, D. D., Awdeh, Z. L., Glass, D., Yunis, E., & Alper, C. A. (1981). The location of C2, C4, and BF relative to HLA-B and HLA-D. Immunogenetics, 12(1), 473-483.