The linear computational algorithm of cerebellar Purkinje cells

Joy T. Walter, Kamran Khodakhah

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The orchestration of simple motor tasks by the cerebellum results in coordinated movement and the maintenance of balance. The cerebellum integrates sensory and cortical information to generate the signals required for the coordinated execution of simple motor tasks. These signals originate in the firing rate of Purkinje cells, each of which integrates sensory and cortical information conveyed by granule cell synaptic inputs. Given the importance of the granule cell input-Purkinje cell output function for cerebellar computation, this algorithm was determined. Using several stimulation paradigms, including those that mimicked patterns of granule cell activity similar to those observed in vivo, we quantified the poststimulus maximum firing rate and number of extra spikes in response to granule cell synaptic input. Both of these parameters linearly encoded the strength of synaptic input when inhibitory synaptic transmission was blocked. This linear algorithm was independent of the location or temporal pattern of synaptic input. With inhibitory synaptic transmission intact, themaximumfiring rate, but not thenumberof extra spikes, encoded the strength of granule cell synaptic input. Furthermore, the maximum firing rate of Purkinje cells linearly encoded the strength of synaptic input whether or not the activation of granule cells resulted in a pause in Purkinje cell firing. On the basis of the data presented, we propose that Purkinje cells encode the strength of granule cell synaptic input in their maximum firing rate with a linear algorithm.

Original languageEnglish (US)
Pages (from-to)12861-12872
Number of pages12
JournalJournal of Neuroscience
Volume26
Issue number50
DOIs
StatePublished - Dec 13 2006

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Purkinje Cells
Synaptic Transmission
Cerebellum
Maintenance

Keywords

  • Activity
  • Cerebellum
  • Computational algorithm
  • Granule cell
  • Purkinje neurons
  • Synaptic communication

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The linear computational algorithm of cerebellar Purkinje cells. / Walter, Joy T.; Khodakhah, Kamran.

In: Journal of Neuroscience, Vol. 26, No. 50, 13.12.2006, p. 12861-12872.

Research output: Contribution to journalArticle

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