The limited capacity of mammalian cells to accumulate free intracellular methotrexate, a critical intracellular component required for inhibition of dihydrofolate reduction to tetrahydrofolate. A basis, in part, for the efficacy of high dose protocols

J. C. White, I. David Goldman, W. Lawrence

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationProceedings of the American Association for Cancer Research
VolumeVol.17
StatePublished - 1976
Externally publishedYes

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Methotrexate
5,6,7,8-tetrahydrofolic acid
dihydrofolate

ASJC Scopus subject areas

  • Medicine(all)

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The limited capacity of mammalian cells to accumulate free intracellular methotrexate, a critical intracellular component required for inhibition of dihydrofolate reduction to tetrahydrofolate. A basis, in part, for the efficacy of high dose protocols. / White, J. C.; Goldman, I. David; Lawrence, W.

Proceedings of the American Association for Cancer Research. Vol. Vol.17 1976.

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Lawrence, W.

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M3 - Chapter

VL - Vol.17

BT - Proceedings of the American Association for Cancer Research

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