The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Research output: Contribution to journalReview article

61 Scopus citations


The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

Original languageEnglish (US)
Pages (from-to)2251-2271
Number of pages21
JournalBiochemical Journal
Issue number15
StatePublished - 2016



  • Autophagy
  • Class III phosphoinositide 3-kinase
  • Endocytosis
  • Phosphoinositide 3-kinase
  • Phosphorylation/ dephosphorylation
  • Vps34

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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