The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

Original languageEnglish (US)
Pages (from-to)2251-2271
Number of pages21
JournalBiochemical Journal
Volume473
Issue number15
DOIs
StatePublished - 2016

Fingerprint

1-Phosphatidylinositol 4-Kinase
Protein Transport
Phosphatidylinositols
Sorting
Phosphotransferases
Proteins
Cytokinesis
Autophagy
Phagocytosis
Nutrients
Lipids
Food
Enzymes

Keywords

  • Autophagy
  • Class III phosphoinositide 3-kinase
  • Endocytosis
  • Phosphoinositide 3-kinase
  • Phosphorylation/ dephosphorylation
  • Vps34

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34. / Backer, Jonathan M.

In: Biochemical Journal, Vol. 473, No. 15, 2016, p. 2251-2271.

Research output: Contribution to journalReview article

@article{26a538b1568843cd8b6702fe46eaa152,
title = "The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34",
abstract = "The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.",
keywords = "Autophagy, Class III phosphoinositide 3-kinase, Endocytosis, Phosphoinositide 3-kinase, Phosphorylation/ dephosphorylation, Vps34",
author = "Backer, {Jonathan M.}",
year = "2016",
doi = "10.1042/BCJ20160170",
language = "English (US)",
volume = "473",
pages = "2251--2271",
journal = "Biochemical Journal",
issn = "0264-6021",
publisher = "Portland Press Ltd.",
number = "15",

}

TY - JOUR

T1 - The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

AU - Backer, Jonathan M.

PY - 2016

Y1 - 2016

N2 - The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

AB - The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

KW - Autophagy

KW - Class III phosphoinositide 3-kinase

KW - Endocytosis

KW - Phosphoinositide 3-kinase

KW - Phosphorylation/ dephosphorylation

KW - Vps34

UR - http://www.scopus.com/inward/record.url?scp=85009423797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009423797&partnerID=8YFLogxK

U2 - 10.1042/BCJ20160170

DO - 10.1042/BCJ20160170

M3 - Review article

C2 - 27470591

AN - SCOPUS:85009423797

VL - 473

SP - 2251

EP - 2271

JO - Biochemical Journal

JF - Biochemical Journal

SN - 0264-6021

IS - 15

ER -