@article{a38fca87b45541dfb64705c609f0a84c,
title = "The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis",
abstract = "Of the ~60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms. Understanding the mechanisms of HPV genomic findings is complicated by the linkage of HPV genome variants. A panel of experts in various disciplines gathered on 21 November 2016 to discuss the interdisciplinary science of HPV oncogenesis. Here, we summarize the discussion of the complexity of the viral–host interaction and highlight important next steps for selected applied basic laboratory studies guided by epidemiological genomic findings.",
keywords = "HPV carcinogenesis, HPV epidemiology, HPV genomics, HPV16, Host interactions, Viral",
author = "{NCI HPV Workshop} and Lisa Mirabello and Clarke, {Megan A.} and Nelson, {Chase W.} and Michael Dean and Nicolas Wentzensen and Meredith Yeager and Michael Cullen and Boland, {Joseph F.} and Laia Alemany and Lawrence Banks and Sara Bass and Chris Buck and Laurie Burdett and Anil Chaturvedi and Gary Clifford and Daniel DiMaio and John Doorbar and Allan Hildesheim and Lou Laimins and Paul Lambert and Hong Lou and Alison McBride and Karl Munger and Ribas, {Miguel Angel Pav{\'o}n} and Ligia Pinto and John Schiller and Richard Schlegel and Stefan Schwartz and Mia Steinberg and Sarah Wagner and Yanzi Xiao and Qi Yang and Kai Yu and Bin Zhu and Mark Schiffman and Burk, {Robert D.}",
note = "Funding Information: Acknowledgments: We thank Zigui Chen (The Chinese University of Hong Kong) for help with the HPV16 phylogenetic tree. This study was funded by the intramural research program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This work was supported in part by the National Cancer Institute (CA78527) and the Einstein Cancer Research Center (P30CA013330) from the National Cancer Institute (to Robert D. Burk). Chase W. Nelson was supported by a Gerstner Scholars Fellowship from the Gerstner Family Foundation at the American Museum of Natural History. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = feb,
day = "13",
doi = "10.3390/v10020080",
language = "English (US)",
volume = "10",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}
