The Intersection of Aging Biology and the Pathobiology of Lung Diseases

A Joint NHLBI/NIA Workshop

G. R.Scott Budinger, Ronald A. Kohanski, Weiniu Gan, Michael S. Kobor, Luis A. Amaral, Mary Armanios, Karl T. Kelsey, Annie Pardo, Rubin Tuder, Fernando Macian-Juan, Navdeep Chandel, Douglas Vaughan, Mauricio Rojas, Ana L. Mora, Elizabeth Kovacs, Steven R. Duncan, Toren Finkel, Augustine Choi, Oliver Eickelberg, Danica Chen & 8 others Alvar Agusti, Moises Selman, William E. Balch, Paula Busse, Anning Lin, Richard Morimoto, Jacob I. Sznajder, Victor J. Thannickal

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Death from chronic lung disease is increasing and chronic obstructive pulmonary disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization, and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as life span. This review summarizes the findings of a joint workshop sponsored by the NIA and NHLBI that brought together investigators focused on aging and lung biology. These investigators encouraged the use of genetic systems and aged animals in the study of lung disease and the development of integrative systems-based platforms that can dynamically incorporate data sets that describe the genomics, transcriptomics, epigenomics, metabolomics, and proteomics of the aging lung in health and disease. Further research was recommended to integrate benchmark biological hallmarks of aging in the lung with the pathobiology of acute and chronic lung diseases with divergent pathologies for which advanced age is the most important risk factor.

Original languageEnglish (US)
Pages (from-to)1492-1500
Number of pages9
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume72
Issue number11
DOIs
StatePublished - Oct 12 2017

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National Heart, Lung, and Blood Institute (U.S.)
Lung Diseases
Joints
Education
Chronic Disease
Lung
Research Personnel
Benchmarking
Metabolomics
Acute Disease
Genomics
Epigenomics
Immobilization
Dyspnea
Proteomics
Chronic Obstructive Pulmonary Disease
Cause of Death
Exercise
Pathology
Morbidity

Keywords

  • Age-related pathology
  • Biology of aging
  • Lungs/pulmonary

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

The Intersection of Aging Biology and the Pathobiology of Lung Diseases : A Joint NHLBI/NIA Workshop. / Budinger, G. R.Scott; Kohanski, Ronald A.; Gan, Weiniu; Kobor, Michael S.; Amaral, Luis A.; Armanios, Mary; Kelsey, Karl T.; Pardo, Annie; Tuder, Rubin; Macian-Juan, Fernando; Chandel, Navdeep; Vaughan, Douglas; Rojas, Mauricio; Mora, Ana L.; Kovacs, Elizabeth; Duncan, Steven R.; Finkel, Toren; Choi, Augustine; Eickelberg, Oliver; Chen, Danica; Agusti, Alvar; Selman, Moises; Balch, William E.; Busse, Paula; Lin, Anning; Morimoto, Richard; Sznajder, Jacob I.; Thannickal, Victor J.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 72, No. 11, 12.10.2017, p. 1492-1500.

Research output: Contribution to journalReview article

Budinger, GRS, Kohanski, RA, Gan, W, Kobor, MS, Amaral, LA, Armanios, M, Kelsey, KT, Pardo, A, Tuder, R, Macian-Juan, F, Chandel, N, Vaughan, D, Rojas, M, Mora, AL, Kovacs, E, Duncan, SR, Finkel, T, Choi, A, Eickelberg, O, Chen, D, Agusti, A, Selman, M, Balch, WE, Busse, P, Lin, A, Morimoto, R, Sznajder, JI & Thannickal, VJ 2017, 'The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 72, no. 11, pp. 1492-1500. https://doi.org/10.1093/gerona/glx090
Budinger, G. R.Scott ; Kohanski, Ronald A. ; Gan, Weiniu ; Kobor, Michael S. ; Amaral, Luis A. ; Armanios, Mary ; Kelsey, Karl T. ; Pardo, Annie ; Tuder, Rubin ; Macian-Juan, Fernando ; Chandel, Navdeep ; Vaughan, Douglas ; Rojas, Mauricio ; Mora, Ana L. ; Kovacs, Elizabeth ; Duncan, Steven R. ; Finkel, Toren ; Choi, Augustine ; Eickelberg, Oliver ; Chen, Danica ; Agusti, Alvar ; Selman, Moises ; Balch, William E. ; Busse, Paula ; Lin, Anning ; Morimoto, Richard ; Sznajder, Jacob I. ; Thannickal, Victor J. / The Intersection of Aging Biology and the Pathobiology of Lung Diseases : A Joint NHLBI/NIA Workshop. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2017 ; Vol. 72, No. 11. pp. 1492-1500.
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AU - Kelsey, Karl T.

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AU - Agusti, Alvar

AU - Selman, Moises

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