TY - JOUR
T1 - The interactions of retinoids with retinol‐binding protein
T2 - A resonance Raman spectroscopic study
AU - MANOR, Dan
AU - CALLENDER, Robert
AU - NOY, Noa
PY - 1993/4
Y1 - 1993/4
N2 - We have measured the pre‐resonance Raman spectrum of retinal, retinoic acid and retinol in dilute CCl4 solutions and when bound to the bovine‐serum retinol‐binding protein. The comparison reveals that the binding interactions does not involve any specific interactions of the head group and/or the polyene chain with a particular protein residue. The data indicate hydrogen bonding of bound retinal's head‐group oxygen to water, as well as some torsional angle change of its polyene chain upon binding.
AB - We have measured the pre‐resonance Raman spectrum of retinal, retinoic acid and retinol in dilute CCl4 solutions and when bound to the bovine‐serum retinol‐binding protein. The comparison reveals that the binding interactions does not involve any specific interactions of the head group and/or the polyene chain with a particular protein residue. The data indicate hydrogen bonding of bound retinal's head‐group oxygen to water, as well as some torsional angle change of its polyene chain upon binding.
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U2 - 10.1111/j.1432-1033.1993.tb17776.x
DO - 10.1111/j.1432-1033.1993.tb17776.x
M3 - Article
C2 - 8477713
AN - SCOPUS:0027394768
SN - 0014-2956
VL - 213
SP - 413
EP - 418
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
IS - 1
ER -