The interactions of retinoids with retinol‐binding protein: A resonance Raman spectroscopic study

Dan MANOR, Robert CALLENDER, Noa NOY

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We have measured the pre‐resonance Raman spectrum of retinal, retinoic acid and retinol in dilute CCl4 solutions and when bound to the bovine‐serum retinol‐binding protein. The comparison reveals that the binding interactions does not involve any specific interactions of the head group and/or the polyene chain with a particular protein residue. The data indicate hydrogen bonding of bound retinal's head‐group oxygen to water, as well as some torsional angle change of its polyene chain upon binding.

Original languageEnglish (US)
Pages (from-to)413-418
Number of pages6
JournalEuropean Journal of Biochemistry
Volume213
Issue number1
DOIs
StatePublished - Apr 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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