The interaction of hyperthermia with fast neutrons or X rays on local tumor response

E. W. Hahn, T. R. Canada, A. A. Alfieri, J. C. McDonald

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Studies were carried out to examine the interactions of local tumor hyperthermia (LTH) with single and multiple doses of fast neutrons as compared to X rays and to gain further information on the possible mechanisms involved in the radiosensitization of tumor tissues. Ridgway osteogenic sarcomas, (1.0±0.1 cm average diameter) grown in both AKR/Jax and AKD2F1/Jax male mice were exposed to single and multiple doses of X irradiation or cyclotron produced neutrons (En∞3.5 MeV) alone or in combination with LTH (42.5±0.5°C for 15 min). Hyperthermia alone produced a transitory retardation in tumor growth. The RBE of single doses of neutrons alone ranged from 2.6 to 3.0 depending on the endpoint observed. LTH did not appreciably increase the effectiveness of single or multiple doses of neutrons. The effect of a single dose of X rays was enhanced by a value ranging from 1.4 to 1.6 and with multiple doses of X rays the radiation enhancement factor (REF) for LTH ranged from 2.2 to 2.4. The increased killing effect on tumor cells, as a result of X rays combined with heat, probably represents heat induced inhibition of tumor cell repair and increased radiosensitivity of the hypoxic cell compartment. On this basis hyperthermia when used in combination with fast neutrons and possibly other high LET radiation thus offers no added advantage to local tumor control.

Original languageEnglish (US)
Pages (from-to)39-56
Number of pages18
JournalRadiation Research
Volume68
Issue number1
StatePublished - 1976
Externally publishedYes

Fingerprint

Fast Neutrons
hyperthermia
fast neutrons
fever
rays
X-radiation
Fever
tumors
X-Rays
neoplasms
Induced Hyperthermia
dosage
Neoplasms
x rays
Neutrons
interactions
neutrons
heat
Hot Temperature
sarcoma

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Hahn, E. W., Canada, T. R., Alfieri, A. A., & McDonald, J. C. (1976). The interaction of hyperthermia with fast neutrons or X rays on local tumor response. Radiation Research, 68(1), 39-56.

The interaction of hyperthermia with fast neutrons or X rays on local tumor response. / Hahn, E. W.; Canada, T. R.; Alfieri, A. A.; McDonald, J. C.

In: Radiation Research, Vol. 68, No. 1, 1976, p. 39-56.

Research output: Contribution to journalArticle

Hahn, EW, Canada, TR, Alfieri, AA & McDonald, JC 1976, 'The interaction of hyperthermia with fast neutrons or X rays on local tumor response', Radiation Research, vol. 68, no. 1, pp. 39-56.
Hahn, E. W. ; Canada, T. R. ; Alfieri, A. A. ; McDonald, J. C. / The interaction of hyperthermia with fast neutrons or X rays on local tumor response. In: Radiation Research. 1976 ; Vol. 68, No. 1. pp. 39-56.
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