The Interaction of Antiarrhythmic Drugs and the Energy for Cardioversion of Chronic Atrial Fibrillation

THOMAS GUARNIERI, Gordon F. Tomaselli, LAWRENCE S.C. GRIFFITH, JEFFREY BRINKER

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Antiarrhythmic drugs may alter the energy for Cardioversion of ventricular arrhythmias. This study compares the energy necessary for cardioverting chronic atrial fibrillation in 57 patients taking type Ia, Ic, or type III antiarrhythmic drugs. Patients taking Ia (n = 22) or III (n = 14) drugs had a median energy for Cardioversion of 100 joules, while the patients taking Ic (n = 17) drugs had a median energy of 200 joules (P = 0.03). There were no differences in the frequency of unsuccessful Cardioversion, There were no serious adverse events in any of the three groups, although three patients in the Ic group had > 3 second pauses after the shock. The data suggest that the use of Ic antiarrhythmic drugs results in a higher energy for cardioversion of atrial fibrillation. However with higher energies, conversion is as successful as for type Ia and type III.

Original languageEnglish (US)
Pages (from-to)1007-1012
Number of pages6
JournalPacing and Clinical Electrophysiology
Volume14
Issue number6
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Electric Countershock
Anti-Arrhythmia Agents
Atrial Fibrillation
Pharmaceutical Preparations
Cardiac Arrhythmias
Shock

Keywords

  • antiarrhythmic drug
  • atrial fibrillation
  • Cardioversion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The Interaction of Antiarrhythmic Drugs and the Energy for Cardioversion of Chronic Atrial Fibrillation. / GUARNIERI, THOMAS; Tomaselli, Gordon F.; GRIFFITH, LAWRENCE S.C.; BRINKER, JEFFREY.

In: Pacing and Clinical Electrophysiology, Vol. 14, No. 6, 01.01.1991, p. 1007-1012.

Research output: Contribution to journalArticle

GUARNIERI, THOMAS ; Tomaselli, Gordon F. ; GRIFFITH, LAWRENCE S.C. ; BRINKER, JEFFREY. / The Interaction of Antiarrhythmic Drugs and the Energy for Cardioversion of Chronic Atrial Fibrillation. In: Pacing and Clinical Electrophysiology. 1991 ; Vol. 14, No. 6. pp. 1007-1012.
@article{9adca9b978234e2ba1d0cbb927fdff07,
title = "The Interaction of Antiarrhythmic Drugs and the Energy for Cardioversion of Chronic Atrial Fibrillation",
abstract = "Antiarrhythmic drugs may alter the energy for Cardioversion of ventricular arrhythmias. This study compares the energy necessary for cardioverting chronic atrial fibrillation in 57 patients taking type Ia, Ic, or type III antiarrhythmic drugs. Patients taking Ia (n = 22) or III (n = 14) drugs had a median energy for Cardioversion of 100 joules, while the patients taking Ic (n = 17) drugs had a median energy of 200 joules (P = 0.03). There were no differences in the frequency of unsuccessful Cardioversion, There were no serious adverse events in any of the three groups, although three patients in the Ic group had > 3 second pauses after the shock. The data suggest that the use of Ic antiarrhythmic drugs results in a higher energy for cardioversion of atrial fibrillation. However with higher energies, conversion is as successful as for type Ia and type III.",
keywords = "antiarrhythmic drug, atrial fibrillation, Cardioversion",
author = "THOMAS GUARNIERI and Tomaselli, {Gordon F.} and GRIFFITH, {LAWRENCE S.C.} and JEFFREY BRINKER",
year = "1991",
month = "1",
day = "1",
doi = "10.1111/j.1540-8159.1991.tb04150.x",
language = "English (US)",
volume = "14",
pages = "1007--1012",
journal = "PACE - Pacing and Clinical Electrophysiology",
issn = "0147-8389",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - The Interaction of Antiarrhythmic Drugs and the Energy for Cardioversion of Chronic Atrial Fibrillation

AU - GUARNIERI, THOMAS

AU - Tomaselli, Gordon F.

AU - GRIFFITH, LAWRENCE S.C.

AU - BRINKER, JEFFREY

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Antiarrhythmic drugs may alter the energy for Cardioversion of ventricular arrhythmias. This study compares the energy necessary for cardioverting chronic atrial fibrillation in 57 patients taking type Ia, Ic, or type III antiarrhythmic drugs. Patients taking Ia (n = 22) or III (n = 14) drugs had a median energy for Cardioversion of 100 joules, while the patients taking Ic (n = 17) drugs had a median energy of 200 joules (P = 0.03). There were no differences in the frequency of unsuccessful Cardioversion, There were no serious adverse events in any of the three groups, although three patients in the Ic group had > 3 second pauses after the shock. The data suggest that the use of Ic antiarrhythmic drugs results in a higher energy for cardioversion of atrial fibrillation. However with higher energies, conversion is as successful as for type Ia and type III.

AB - Antiarrhythmic drugs may alter the energy for Cardioversion of ventricular arrhythmias. This study compares the energy necessary for cardioverting chronic atrial fibrillation in 57 patients taking type Ia, Ic, or type III antiarrhythmic drugs. Patients taking Ia (n = 22) or III (n = 14) drugs had a median energy for Cardioversion of 100 joules, while the patients taking Ic (n = 17) drugs had a median energy of 200 joules (P = 0.03). There were no differences in the frequency of unsuccessful Cardioversion, There were no serious adverse events in any of the three groups, although three patients in the Ic group had > 3 second pauses after the shock. The data suggest that the use of Ic antiarrhythmic drugs results in a higher energy for cardioversion of atrial fibrillation. However with higher energies, conversion is as successful as for type Ia and type III.

KW - antiarrhythmic drug

KW - atrial fibrillation

KW - Cardioversion

UR - http://www.scopus.com/inward/record.url?scp=0025856877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025856877&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8159.1991.tb04150.x

DO - 10.1111/j.1540-8159.1991.tb04150.x

M3 - Article

VL - 14

SP - 1007

EP - 1012

JO - PACE - Pacing and Clinical Electrophysiology

JF - PACE - Pacing and Clinical Electrophysiology

SN - 0147-8389

IS - 6

ER -