The interaction between microglia and neural stem/precursor cells

Peng Su, Jianbin Zhang, Fang Zhao, Michael Aschner, Jingyuan Chen, Wenjing Luo

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalBrain Research Bulletin
Volume109
DOIs
StatePublished - Jan 1 2014

Keywords

  • Coculture
  • Microglia
  • Neural stem/precursor cells
  • Neurogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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