TY - JOUR
T1 - The insulin/IGF-1 signaling in mammals and its relevance to human longevity
AU - Rincon, Marielisa
AU - Rudin, Eric
AU - Barzilai, Nir
N1 - Funding Information:
Dr Barzilai's research in animal models is supported by grants from the National Institute of Health (RO1-AG18381, and P01-AG021654). The longevity study was supported by grants from the Paul Beeson Physician Faculty Scholar in Aging Award, the Ellison Medical Foundation Senior Scholar Award, and RO1 (AG-18728), and the Diabetes Research and Training Center (DK 20541) at the Albert Einstein College of Medicine.
PY - 2005/11
Y1 - 2005/11
N2 - Hormones, like insulin and insulin-like growth factor 1 (IGF-1), are thought to be deeply involved with longevity. Lower species have been the source for most of our current knowledge on the role of the insulin/IGF-1 signaling in modulating lifespan. This hormonal system may have originated from a very early common ancestor and is involved in many functions that are necessary for metabolism, growth, and fertility in animal models like flies, nematodes and mammalians. Disruption of the insulin/IGF-1 receptor in nematodes and flies increases lifespan significantly. With evolution, mammals developed two well characterized hormonal systems: insulin and growth hormone (GH)/IGF-1, with different metabolic and developmental functions. Abnormalities in the insulin signaling pathway generate age-related diseases and increased mortality, whereas the GH/IGF-1 axis could potentially modulate longevity in many species. In this review we briefly describe the lifespan regulatory role of the insulin/IGF-1 signaling of nematodes, flies and rodent models and compare it with the human equivalent.
AB - Hormones, like insulin and insulin-like growth factor 1 (IGF-1), are thought to be deeply involved with longevity. Lower species have been the source for most of our current knowledge on the role of the insulin/IGF-1 signaling in modulating lifespan. This hormonal system may have originated from a very early common ancestor and is involved in many functions that are necessary for metabolism, growth, and fertility in animal models like flies, nematodes and mammalians. Disruption of the insulin/IGF-1 receptor in nematodes and flies increases lifespan significantly. With evolution, mammals developed two well characterized hormonal systems: insulin and growth hormone (GH)/IGF-1, with different metabolic and developmental functions. Abnormalities in the insulin signaling pathway generate age-related diseases and increased mortality, whereas the GH/IGF-1 axis could potentially modulate longevity in many species. In this review we briefly describe the lifespan regulatory role of the insulin/IGF-1 signaling of nematodes, flies and rodent models and compare it with the human equivalent.
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U2 - 10.1016/j.exger.2005.06.014
DO - 10.1016/j.exger.2005.06.014
M3 - Review article
C2 - 16168602
AN - SCOPUS:27544434895
SN - 0531-5565
VL - 40
SP - 873
EP - 877
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 11
ER -