The Ins and Outs of MHC Class II Proteins in Dendritic Cells

Laura Santambrogio, Jack L. Strominger

Research output: Contribution to journalShort survey

12 Scopus citations


One more mechanism for regulating surface expression of MHC class II proteins in dendritic cells (an important process that regulates both tolerance and immunity) has been uncovered, polyubiquitination of Lys225 in the intracytoplasmic region and subsequent endocytosis and proteolysis (Omura-Hoshino et al., 2006; van Neil et al., 2006; Shin et al., 2006).

Original languageEnglish (US)
Pages (from-to)857-859
Number of pages3
Issue number6
Publication statusPublished - Dec 1 2006


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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