The initial vascular access type contributes to inflammation in incident hemodialysis patients

Mala Sachdeva, Adriana Hung, Oleksandr Kovalchuk, Markus Bitzer, Michele H. Mokrzycki

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. The contribution of the hemodialysis (HD) vascular access type to inflammation is unclear. Methods. We conducted a prospective observational study in an incident HD population. C-reactive protein (CRP), interleukin-6 (IL-6), and interferon-γ-induced protein (IP-10) were measured before and at 6-time points after access placement for 1 year. Results. Sixty-four incident HD patients were included (tunneled catheter (TC), n = 40, arteriovenous fistula (AVF), n = 14, and arteriovenous graft (AVG), n = 10). A mixed effects model was performed to adjust for age, sex, race, coronary artery disease, diabetes mellitus, infections, access thrombosis, initiation of HD, and days after access surgery. In comparison to AVFs, the presence of a TC was associated with significantly higher levels of CRP (P = 0.03), IL-6 (P = 0.07), and IP-10 (P = 0.03). The presence of an AVG was associated with increases in CRP (P = 0.01) and IP-10 (P = 0.07). Conclusions. Patients who initiate HD with a TC or an AVG have a heightened state of inflammation, which may contribute to the excess 90-day mortality after HD initiation.

Original languageEnglish (US)
Article number917465
JournalInternational Journal of Nephrology
Volume2012
DOIs
StatePublished - 2012

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Blood Vessels
Renal Dialysis
Inflammation
C-Reactive Protein
Catheters
Transplants
Interleukin-6
Arteriovenous Fistula
Interferons
Observational Studies
Coronary Artery Disease
Diabetes Mellitus
Thrombosis
Prospective Studies
Mortality
Infection
Population
Proteins

ASJC Scopus subject areas

  • Nephrology

Cite this

The initial vascular access type contributes to inflammation in incident hemodialysis patients. / Sachdeva, Mala; Hung, Adriana; Kovalchuk, Oleksandr; Bitzer, Markus; Mokrzycki, Michele H.

In: International Journal of Nephrology, Vol. 2012, 917465, 2012.

Research output: Contribution to journalArticle

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