The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

Robert W. Downs, Ronald D. Sekura, Michael A. Levine, Allen M. Spiegel

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Deficient activity of the adenylate cyclase stimulatory coupling protein (N8) has been demonstrated in many patients with pseudohypoparathyroidism type I (PHP) who have Albright’s hereditary osteodystrophy and multiple hormone resistance. Since an abnormality in the activity of the related adenylate cyclase inhibitory coupling protein (Ni) could influence hormone responsiveness, we measured pertussistoxincatalyzed [32P]ADP ribosylation of the 40, 000-dalton α-subunit of Ni (Niα) in erythrocyte membranes from patients with PHP and normal subjects. There were no significant differences in the amounts of Niα in membranes from normal subjects, patients with PHP who have low N8 associated with Albright’s hereditary osteodystrophy and multiple hormone resistance, and patients with PHP who have normal N8. Abnormal Ni is not likely to cause hormone resistance in patients with PHP who have normal N9 or to influence hormone responsiveness in patients with PHP who have low N8.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume61
Issue number2
DOIs
StatePublished - Aug 1985
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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