The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

Robert W. Downs; Ronald D. Sekura; Michael A. Levine; Allen M. Spiegel

doi:10.1210/jcem-61-2-351

The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

Robert W. Downs, Ronald D. Sekura, Michael A. Levine, Allen M. Spiegel

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Deficient activity of the adenylate cyclase stimulatory coupling protein (N₈) has been demonstrated in many patients with pseudohypoparathyroidism type I (PHP) who have Albright’s hereditary osteodystrophy and multiple hormone resistance. Since an abnormality in the activity of the related adenylate cyclase inhibitory coupling protein (N_i) could influence hormone responsiveness, we measured pertussistoxincatalyzed [³²P]ADP ribosylation of the 40, 000-dalton α-subunit of N_i (N_iα) in erythrocyte membranes from patients with PHP and normal subjects. There were no significant differences in the amounts of N_iα in membranes from normal subjects, patients with PHP who have low N₈ associated with Albright’s hereditary osteodystrophy and multiple hormone resistance, and patients with PHP who have normal N₈. Abnormal N_i is not likely to cause hormone resistance in patients with PHP who have normal N₉ or to influence hormone responsiveness in patients with PHP who have low N₈.

Original language	English (US)
Pages (from-to)	351-354
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	61
Issue number	2
DOIs	https://doi.org/10.1210/jcem-61-2-351
State	Published - Aug 1985
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-61-2-351

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title = "The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism",

abstract = "Deficient activity of the adenylate cyclase stimulatory coupling protein (N8) has been demonstrated in many patients with pseudohypoparathyroidism type I (PHP) who have Albright{\textquoteright}s hereditary osteodystrophy and multiple hormone resistance. Since an abnormality in the activity of the related adenylate cyclase inhibitory coupling protein (Ni) could influence hormone responsiveness, we measured pertussistoxincatalyzed [32P]ADP ribosylation of the 40, 000-dalton α-subunit of Ni (Niα) in erythrocyte membranes from patients with PHP and normal subjects. There were no significant differences in the amounts of Niα in membranes from normal subjects, patients with PHP who have low N8 associated with Albright{\textquoteright}s hereditary osteodystrophy and multiple hormone resistance, and patients with PHP who have normal N8. Abnormal Ni is not likely to cause hormone resistance in patients with PHP who have normal N9 or to influence hormone responsiveness in patients with PHP who have low N8.",

author = "Downs, {Robert W.} and Sekura, {Ronald D.} and Levine, {Michael A.} and Spiegel, {Allen M.}",

year = "1985",

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doi = "10.1210/jcem-61-2-351",

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T1 - The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

AU - Downs, Robert W.

AU - Sekura, Ronald D.

AU - Levine, Michael A.

AU - Spiegel, Allen M.

PY - 1985/8

Y1 - 1985/8

N2 - Deficient activity of the adenylate cyclase stimulatory coupling protein (N8) has been demonstrated in many patients with pseudohypoparathyroidism type I (PHP) who have Albright’s hereditary osteodystrophy and multiple hormone resistance. Since an abnormality in the activity of the related adenylate cyclase inhibitory coupling protein (Ni) could influence hormone responsiveness, we measured pertussistoxincatalyzed [32P]ADP ribosylation of the 40, 000-dalton α-subunit of Ni (Niα) in erythrocyte membranes from patients with PHP and normal subjects. There were no significant differences in the amounts of Niα in membranes from normal subjects, patients with PHP who have low N8 associated with Albright’s hereditary osteodystrophy and multiple hormone resistance, and patients with PHP who have normal N8. Abnormal Ni is not likely to cause hormone resistance in patients with PHP who have normal N9 or to influence hormone responsiveness in patients with PHP who have low N8.

AB - Deficient activity of the adenylate cyclase stimulatory coupling protein (N8) has been demonstrated in many patients with pseudohypoparathyroidism type I (PHP) who have Albright’s hereditary osteodystrophy and multiple hormone resistance. Since an abnormality in the activity of the related adenylate cyclase inhibitory coupling protein (Ni) could influence hormone responsiveness, we measured pertussistoxincatalyzed [32P]ADP ribosylation of the 40, 000-dalton α-subunit of Ni (Niα) in erythrocyte membranes from patients with PHP and normal subjects. There were no significant differences in the amounts of Niα in membranes from normal subjects, patients with PHP who have low N8 associated with Albright’s hereditary osteodystrophy and multiple hormone resistance, and patients with PHP who have normal N8. Abnormal Ni is not likely to cause hormone resistance in patients with PHP who have normal N9 or to influence hormone responsiveness in patients with PHP who have low N8.

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The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

Abstract

ASJC Scopus subject areas

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