The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects

I. N. Cholst, S. F. Steinberg, P. J. Tropper, H. E. Fox, G. V. Segre, J. P. Bilezikian

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Abstract

We measured serum concentrations of calcium and parathyroid hormone in seven pregnant women who were receiving intravenous magnesium sulfate for the suppression of premature labor. After administration of magnesium sulfate, the mean (±S.E.M.) serum magnesium level rose rapidly from the normal base-line level of 2.0 ± 0.2 mg per deciliter to 6.1 ± 0.4 mg per deciliter (0.8 ± 0.1 to 2.5 ± 0.2 mmol per liter) (P < 0.001) at 30 minutes and remained markedly elevated. Concentrations of total and ionized calcium fell gradually in all subjects from normal base-line concentrations, 8.6 ± 0.2 and 4.4 ± 0.1 mg per deciliter (2.2 ± 0.1 and 1.1 ± 0.03 mmol per liter), respectively, into the hypocalcemic range, reaching a nadir of 7.6 ± 0.2 and 3.9 ± 0.1 mg per deciliter (1.9 ± 0.1 and 0.98 ± 0.03 mmol per liter), respectively, at three hours (P < 0.001). Parathyroid hormone levels fell rapidly in response to magnesium infusion, from 13.1 ± 2.5 to 7.8 ± 0.7 pg per milliliter at 30 minutes, and were significantly below base-line levels for two hours despite frank hypocalcemia. These results suggest that hypermagnesemia rapidly decreases the secretion of parathyroid hormone in vivo in human subjects and that parathyroid hormone levels remain depressed despite concomitant hypocalcemia. The results also suggest that the hypocalcemia associated with hypermagnesemia may be due in part to the suppressive effects of hypermagnesemia on parathyroid hormone secretion.

Original languageEnglish (US)
Pages (from-to)1221-1225
Number of pages5
JournalNew England Journal of Medicine
Volume310
Issue number19
StatePublished - 1984
Externally publishedYes

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Parathyroid Hormone
Hypocalcemia
Calcium
Magnesium Sulfate
Serum
Magnesium
Premature Obstetric Labor
Pregnant Women

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cholst, I. N., Steinberg, S. F., Tropper, P. J., Fox, H. E., Segre, G. V., & Bilezikian, J. P. (1984). The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. New England Journal of Medicine, 310(19), 1221-1225.

The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. / Cholst, I. N.; Steinberg, S. F.; Tropper, P. J.; Fox, H. E.; Segre, G. V.; Bilezikian, J. P.

In: New England Journal of Medicine, Vol. 310, No. 19, 1984, p. 1221-1225.

Research output: Contribution to journalArticle

Cholst, IN, Steinberg, SF, Tropper, PJ, Fox, HE, Segre, GV & Bilezikian, JP 1984, 'The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects', New England Journal of Medicine, vol. 310, no. 19, pp. 1221-1225.
Cholst IN, Steinberg SF, Tropper PJ, Fox HE, Segre GV, Bilezikian JP. The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. New England Journal of Medicine. 1984;310(19):1221-1225.
Cholst, I. N. ; Steinberg, S. F. ; Tropper, P. J. ; Fox, H. E. ; Segre, G. V. ; Bilezikian, J. P. / The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. In: New England Journal of Medicine. 1984 ; Vol. 310, No. 19. pp. 1221-1225.
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AU - Bilezikian, J. P.

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