To assess the effects of airway conductance (Gaw) and respiratory muscle strength (RMS) on maximal voluntary ventilation (MVV), we studied 8 normal subjects (N), 8 patients with interstitial lung disease (ILD), and 16 with chronic airflow limitation (CAL). In the patients with ILD, RMS explains 83% of the variance in MVV (p < 0.005), but Gaw explains none. In the patients with CAL, Gaw and RMS explain, respectively, 65 and 34% of the variance in MVV (p < 0.02). Considering Gaw and RMS together increases the explained variance to 77% (p < 0.005). In groups CAL and N combined, Gaw and RMS explain 86% of the variance in MVV, with 71% explained by Gaw and 34% by RMS, which the other variable alone failed to explain (p < 0.005). When the data are normalized for age, sex, height, and lung volume, the influence of %RMS on %MVV is halved, but remains significant (p < 0.05). We conclude that RMS is a primary determinant of MVV in patients with ILD, and an important determinant in patients with CAL.
|Original language||English (US)|
|Number of pages||5|
|Journal||American Review of Respiratory Disease|
|Publication status||Published - Jan 1 1982|
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine