The influence of airway obstruction and respiratory muscle strength on maximal voluntary ventilation in lung disease

T. K. Aldrich, N. S. Arora, D. F. Rochester

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To assess the effects of airway conductance (Gaw) and respiratory muscle strength (RMS) on maximal voluntary ventilation (MVV), we studied 8 normal subjects (N), 8 patients with interstitial lung disease (ILD), and 16 with chronic airflow limitation (CAL). In the patients with ILD, RMS explains 83% of the variance in MVV (p < 0.005), but Gaw explains none. In the patients with CAL, Gaw and RMS explain, respectively, 65 and 34% of the variance in MVV (p < 0.02). Considering Gaw and RMS together increases the explained variance to 77% (p < 0.005). In groups CAL and N combined, Gaw and RMS explain 86% of the variance in MVV, with 71% explained by Gaw and 34% by RMS, which the other variable alone failed to explain (p < 0.005). When the data are normalized for age, sex, height, and lung volume, the influence of %RMS on %MVV is halved, but remains significant (p < 0.05). We conclude that RMS is a primary determinant of MVV in patients with ILD, and an important determinant in patients with CAL.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalAmerican Review of Respiratory Disease
Issue number2
Publication statusPublished - Jan 1 1982


ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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