The influence of age at onset and duration of illness on long-term outcome in patients with obsessive-compulsive disorder: A report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS)

Bernardo Dell'Osso, Beatrice Benatti, Massimiliano Buoli, A. Carlo Altamura, Donatella Marazziti, Eric Hollander, Naomi Fineberg, Dan J. Stein, Stefano Pallanti, Humberto Nicolini, Michael Van Ameringen, Christine Lochner, Georgi Hranov, Oguz Karamustafalioglu, Luchezar Hranov, Jose M. Menchon, Joseph Zohar

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Several studies reported a negative effect of early onset and long duration of illness on long-term outcome in psychiatric disorders, including Obsessive-Compulsive Disorder (OCD). OCD is a prevalent, comorbid and disabling condition, associated with reduced quality of life and overall well-being for affected patients and related caregivers. The present multicenter naturalistic study sought to assess the influence of early onset and duration of illness on long-term outcome in a sample of 376 OCD out-patients worldwide, as part of the "International College of Obsessive-Compulsive Spectrum Disorders" (ICOCS) network. Binary logistic regressions were performed with age at the onset and duration of illness, as continuous independent variables, on a series of different outcome dependent variables, including lifetime number of hospitalizations and suicide attempts, poly-therapy and psychiatric comorbidity. Correlations in terms of disability (SDS) were analyzed as well. Results showed that a longer duration of illness (but not earlier age of onset) was associated with hospitalization (odds ratio=1.03, p=0.01), earlier age at onset with CBT (odds ratio=0.94, p<0.001) and both a later age at onset (odds ratio=1.05, p=0.02) and a shorter duration of illness (odds ratio=0.93, p=0.02) with panic disorder comorbidity. In addition, earlier age at onset inversely correlated with higher social disability (r=-0.12, p=0.048) and longer duration of illness directly correlated with higher disability in work, social and family life (r=0.14, p=0.017; r=0.13, p=0.035; r=0.14, p=0.02). The findings from the present large, multicenter study indicate early onset and long duration of illness as overall negative predictors of long-term outcome in OCD.

Original languageEnglish (US)
Pages (from-to)865-871
Number of pages7
JournalEuropean Neuropsychopharmacology
Volume23
Issue number8
DOIs
StatePublished - Aug 2013

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Obsessive-Compulsive Disorder
Age of Onset
Odds Ratio
Multicenter Studies
Psychiatry
Comorbidity
Hospitalization
Panic Disorder
Suicide
Caregivers
Outpatients
Logistic Models
Quality of Life

Keywords

  • Duration of illness
  • Early onset
  • Long-term outcome
  • Obsessive compulsive disorder (OCD)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Biological Psychiatry
  • Neurology
  • Pharmacology

Cite this

The influence of age at onset and duration of illness on long-term outcome in patients with obsessive-compulsive disorder : A report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS). / Dell'Osso, Bernardo; Benatti, Beatrice; Buoli, Massimiliano; Altamura, A. Carlo; Marazziti, Donatella; Hollander, Eric; Fineberg, Naomi; Stein, Dan J.; Pallanti, Stefano; Nicolini, Humberto; Ameringen, Michael Van; Lochner, Christine; Hranov, Georgi; Karamustafalioglu, Oguz; Hranov, Luchezar; Menchon, Jose M.; Zohar, Joseph.

In: European Neuropsychopharmacology, Vol. 23, No. 8, 08.2013, p. 865-871.

Research output: Contribution to journalArticle

Dell'Osso, B, Benatti, B, Buoli, M, Altamura, AC, Marazziti, D, Hollander, E, Fineberg, N, Stein, DJ, Pallanti, S, Nicolini, H, Ameringen, MV, Lochner, C, Hranov, G, Karamustafalioglu, O, Hranov, L, Menchon, JM & Zohar, J 2013, 'The influence of age at onset and duration of illness on long-term outcome in patients with obsessive-compulsive disorder: A report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS)', European Neuropsychopharmacology, vol. 23, no. 8, pp. 865-871. https://doi.org/10.1016/j.euroneuro.2013.05.004
Dell'Osso, Bernardo ; Benatti, Beatrice ; Buoli, Massimiliano ; Altamura, A. Carlo ; Marazziti, Donatella ; Hollander, Eric ; Fineberg, Naomi ; Stein, Dan J. ; Pallanti, Stefano ; Nicolini, Humberto ; Ameringen, Michael Van ; Lochner, Christine ; Hranov, Georgi ; Karamustafalioglu, Oguz ; Hranov, Luchezar ; Menchon, Jose M. ; Zohar, Joseph. / The influence of age at onset and duration of illness on long-term outcome in patients with obsessive-compulsive disorder : A report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS). In: European Neuropsychopharmacology. 2013 ; Vol. 23, No. 8. pp. 865-871.
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