The inflammatory and coagulative response to prolonged extracorporeal membrane oxygenation

Giles J. Peek, Richard K. Firmin

Research output: Contribution to journalReview article

88 Scopus citations


Extracorporeal circulation is used therapeutically during renal dialysis, cardiopulmonary bypass (CPB), and extracorporeal membrane oxygenation (ECMO). All of these procedures result in activation of the body's natural defense mechanisms against 'nonself' and foreign invasion. The prolonged duration of ECMO compared with other applications and the absence of hypothermia, hemodilution, ischemia/reperfusion, and protamine administration make the host response to ECMO subtly distinct. In this review, the host response to ECMO is discussed and contrasted to CPB. The use of aprotinin and other response modifiers is also considered.

Original languageEnglish (US)
Pages (from-to)250-263
Number of pages14
JournalASAIO Journal
Issue number4
Publication statusPublished - Jan 1 1999

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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