Abstract
Extracorporeal circulation is used therapeutically during renal dialysis, cardiopulmonary bypass (CPB), and extracorporeal membrane oxygenation (ECMO). All of these procedures result in activation of the body's natural defense mechanisms against 'nonself' and foreign invasion. The prolonged duration of ECMO compared with other applications and the absence of hypothermia, hemodilution, ischemia/reperfusion, and protamine administration make the host response to ECMO subtly distinct. In this review, the host response to ECMO is discussed and contrasted to CPB. The use of aprotinin and other response modifiers is also considered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 250-263 |
| Number of pages | 14 |
| Journal | ASAIO Journal |
| Volume | 45 |
| Issue number | 4 |
| State | Published - 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Bioengineering
Cite this
The inflammatory and coagulative response to prolonged extracorporeal membrane oxygenation. / Peek, Giles J.; Firmin, Richard K.
In: ASAIO Journal, Vol. 45, No. 4, 1999, p. 250-263.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The inflammatory and coagulative response to prolonged extracorporeal membrane oxygenation
AU - Peek, Giles J.
AU - Firmin, Richard K.
PY - 1999
Y1 - 1999
N2 - Extracorporeal circulation is used therapeutically during renal dialysis, cardiopulmonary bypass (CPB), and extracorporeal membrane oxygenation (ECMO). All of these procedures result in activation of the body's natural defense mechanisms against 'nonself' and foreign invasion. The prolonged duration of ECMO compared with other applications and the absence of hypothermia, hemodilution, ischemia/reperfusion, and protamine administration make the host response to ECMO subtly distinct. In this review, the host response to ECMO is discussed and contrasted to CPB. The use of aprotinin and other response modifiers is also considered.
AB - Extracorporeal circulation is used therapeutically during renal dialysis, cardiopulmonary bypass (CPB), and extracorporeal membrane oxygenation (ECMO). All of these procedures result in activation of the body's natural defense mechanisms against 'nonself' and foreign invasion. The prolonged duration of ECMO compared with other applications and the absence of hypothermia, hemodilution, ischemia/reperfusion, and protamine administration make the host response to ECMO subtly distinct. In this review, the host response to ECMO is discussed and contrasted to CPB. The use of aprotinin and other response modifiers is also considered.
UR - http://www.scopus.com/inward/record.url?scp=0033492795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033492795&partnerID=8YFLogxK
M3 - Review article
C2 - 10445729
AN - SCOPUS:0033492795
VL - 45
SP - 250
EP - 263
JO - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JF - ASAIO journal (American Society for Artificial Internal Organs : 1992)
SN - 1058-2916
IS - 4
ER -