The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York

The Manhattan Lupus Surveillance Program

Peter M. Izmirly, Isabella Wan, Sara Sahl, Jill P. Buyon, H. Michael Belmont, Jane E. Salmon, Anca Askanase, Joan M. Bathon, Laura Geraldino-Pardilla, Yousaf Ali, Ellen M. Ginzler, Chaim Putterman, Caroline Gordon, Charles G. Helmick, Hilary Parton

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking. Methods: We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases. Cases were defined according to the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or the treating rheumatologist's diagnosis. Rates among Manhattan residents were age-standardized, and capture-recapture analyses were conducted to assess case underascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years, respectively. Rates were ∼9 times higher in women than in men for prevalence (107.4 versus 12.5) and incidence (7.9 versus 1.0). Compared with non-Hispanic white women (64.3), prevalence was higher among non-Hispanic black (210.9), Hispanic (138.3), and non-Hispanic Asian (91.2) women. Incidence rates were higher among non-Hispanic black women (15.7) compared with non-Hispanic Asian (6.6), Hispanic (6.5), and non-Hispanic white (6.5) women. Capture-recapture adjustment increased the prevalence and incidence rates (75.9 and 6.0, respectively). Alternate SLE definitions without capture-recapture adjustment revealed higher age-standardized prevalence and incidence rates (73.8 and 6.2, respectively, by the SLICC definition and 72.6 and 5.0 by the rheumatologist definition) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and provides estimates using the SLICC criteria.

Original languageEnglish (US)
JournalArthritis and Rheumatology
DOIs
StateAccepted/In press - 2017

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Systemic Lupus Erythematosus
Hispanic Americans
Incidence
Rheumatology
Registries
Hospital Records
Databases
Population
Rheumatologists

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York : The Manhattan Lupus Surveillance Program. / Izmirly, Peter M.; Wan, Isabella; Sahl, Sara; Buyon, Jill P.; Belmont, H. Michael; Salmon, Jane E.; Askanase, Anca; Bathon, Joan M.; Geraldino-Pardilla, Laura; Ali, Yousaf; Ginzler, Ellen M.; Putterman, Chaim; Gordon, Caroline; Helmick, Charles G.; Parton, Hilary.

In: Arthritis and Rheumatology, 2017.

Research output: Contribution to journalArticle

Izmirly, PM, Wan, I, Sahl, S, Buyon, JP, Belmont, HM, Salmon, JE, Askanase, A, Bathon, JM, Geraldino-Pardilla, L, Ali, Y, Ginzler, EM, Putterman, C, Gordon, C, Helmick, CG & Parton, H 2017, 'The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program', Arthritis and Rheumatology. https://doi.org/10.1002/art.40192
Izmirly, Peter M. ; Wan, Isabella ; Sahl, Sara ; Buyon, Jill P. ; Belmont, H. Michael ; Salmon, Jane E. ; Askanase, Anca ; Bathon, Joan M. ; Geraldino-Pardilla, Laura ; Ali, Yousaf ; Ginzler, Ellen M. ; Putterman, Chaim ; Gordon, Caroline ; Helmick, Charles G. ; Parton, Hilary. / The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York : The Manhattan Lupus Surveillance Program. In: Arthritis and Rheumatology. 2017.
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title = "The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program",
abstract = "Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking. Methods: We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases. Cases were defined according to the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or the treating rheumatologist's diagnosis. Rates among Manhattan residents were age-standardized, and capture-recapture analyses were conducted to assess case underascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years, respectively. Rates were ∼9 times higher in women than in men for prevalence (107.4 versus 12.5) and incidence (7.9 versus 1.0). Compared with non-Hispanic white women (64.3), prevalence was higher among non-Hispanic black (210.9), Hispanic (138.3), and non-Hispanic Asian (91.2) women. Incidence rates were higher among non-Hispanic black women (15.7) compared with non-Hispanic Asian (6.6), Hispanic (6.5), and non-Hispanic white (6.5) women. Capture-recapture adjustment increased the prevalence and incidence rates (75.9 and 6.0, respectively). Alternate SLE definitions without capture-recapture adjustment revealed higher age-standardized prevalence and incidence rates (73.8 and 6.2, respectively, by the SLICC definition and 72.6 and 5.0 by the rheumatologist definition) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and provides estimates using the SLICC criteria.",
author = "Izmirly, {Peter M.} and Isabella Wan and Sara Sahl and Buyon, {Jill P.} and Belmont, {H. Michael} and Salmon, {Jane E.} and Anca Askanase and Bathon, {Joan M.} and Laura Geraldino-Pardilla and Yousaf Ali and Ginzler, {Ellen M.} and Chaim Putterman and Caroline Gordon and Helmick, {Charles G.} and Hilary Parton",
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T1 - The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York

T2 - The Manhattan Lupus Surveillance Program

AU - Izmirly, Peter M.

AU - Wan, Isabella

AU - Sahl, Sara

AU - Buyon, Jill P.

AU - Belmont, H. Michael

AU - Salmon, Jane E.

AU - Askanase, Anca

AU - Bathon, Joan M.

AU - Geraldino-Pardilla, Laura

AU - Ali, Yousaf

AU - Ginzler, Ellen M.

AU - Putterman, Chaim

AU - Gordon, Caroline

AU - Helmick, Charles G.

AU - Parton, Hilary

PY - 2017

Y1 - 2017

N2 - Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking. Methods: We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases. Cases were defined according to the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or the treating rheumatologist's diagnosis. Rates among Manhattan residents were age-standardized, and capture-recapture analyses were conducted to assess case underascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years, respectively. Rates were ∼9 times higher in women than in men for prevalence (107.4 versus 12.5) and incidence (7.9 versus 1.0). Compared with non-Hispanic white women (64.3), prevalence was higher among non-Hispanic black (210.9), Hispanic (138.3), and non-Hispanic Asian (91.2) women. Incidence rates were higher among non-Hispanic black women (15.7) compared with non-Hispanic Asian (6.6), Hispanic (6.5), and non-Hispanic white (6.5) women. Capture-recapture adjustment increased the prevalence and incidence rates (75.9 and 6.0, respectively). Alternate SLE definitions without capture-recapture adjustment revealed higher age-standardized prevalence and incidence rates (73.8 and 6.2, respectively, by the SLICC definition and 72.6 and 5.0 by the rheumatologist definition) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and provides estimates using the SLICC criteria.

AB - Objective: The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking. Methods: We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases. Cases were defined according to the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or the treating rheumatologist's diagnosis. Rates among Manhattan residents were age-standardized, and capture-recapture analyses were conducted to assess case underascertainment. Results: By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years, respectively. Rates were ∼9 times higher in women than in men for prevalence (107.4 versus 12.5) and incidence (7.9 versus 1.0). Compared with non-Hispanic white women (64.3), prevalence was higher among non-Hispanic black (210.9), Hispanic (138.3), and non-Hispanic Asian (91.2) women. Incidence rates were higher among non-Hispanic black women (15.7) compared with non-Hispanic Asian (6.6), Hispanic (6.5), and non-Hispanic white (6.5) women. Capture-recapture adjustment increased the prevalence and incidence rates (75.9 and 6.0, respectively). Alternate SLE definitions without capture-recapture adjustment revealed higher age-standardized prevalence and incidence rates (73.8 and 6.2, respectively, by the SLICC definition and 72.6 and 5.0 by the rheumatologist definition) than the ACR definition, with similar patterns by sex and race/ethnicity. Conclusion: The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and provides estimates using the SLICC criteria.

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