The inactivation of antithrombin III by serum elastase in patients with surgical infections

J. R. Cohen, I. Sarfati, E. Birnbaum, Teresa Benacquista, L. Wise

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The relationship between serum elastase and antithrombin III was determined in septic surgical patients as a possible mechanism for intravascular thrombosis and hypercoagulability during sepsis. Eighteen patients with surgical infections and elevated white blood cell counts had their blood assayed daily for white blood cell count, serum elastase, and antithrombin III, until the patient's white blood cell count returned to normal. Antithrombin III was significantly lower (0.87%) when elastase was above the normal range (> 14.2 μg/ml). Elastase was significantly higher (30.6 μg/ml), when antithrombin III was less than normal. These data indicate that elevated serum elastase is associated with a significant reduction in circulating antithrombin III. Stimuli that increase serum elastase, i.e. surgery, trauma, or sepsis may promote intravascular thrombosis by the inhibition of antithrombin III at the blood-endothelial cell interface.

Original languageEnglish (US)
Pages (from-to)665-667
Number of pages3
JournalAmerican Surgeon
Volume56
Issue number11
StatePublished - 1990

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Antithrombin III
Pancreatic Elastase
Infection
Serum
Leukocyte Count
Sepsis
Thrombosis
Thrombophilia
Blood Cells
Reference Values
Endothelial Cells
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

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The inactivation of antithrombin III by serum elastase in patients with surgical infections. / Cohen, J. R.; Sarfati, I.; Birnbaum, E.; Benacquista, Teresa; Wise, L.

In: American Surgeon, Vol. 56, No. 11, 1990, p. 665-667.

Research output: Contribution to journalArticle

Cohen, JR, Sarfati, I, Birnbaum, E, Benacquista, T & Wise, L 1990, 'The inactivation of antithrombin III by serum elastase in patients with surgical infections', American Surgeon, vol. 56, no. 11, pp. 665-667.
Cohen, J. R. ; Sarfati, I. ; Birnbaum, E. ; Benacquista, Teresa ; Wise, L. / The inactivation of antithrombin III by serum elastase in patients with surgical infections. In: American Surgeon. 1990 ; Vol. 56, No. 11. pp. 665-667.
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