The impact of using donor sperm in assisted reproductive technology cycles on perinatal outcomes

Bo Yu, Rani Fritz, Xianhong Xie, Abdissa Negassa, Sangita K. Jindal, Mario Vega, Erkan Buyuk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To assess the impact of using donor sperm in assisted reproductive technology (ART) cycles on perinatal outcomes. Design: Historical cohort study. Setting: US national database from the Society of Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) from 2012 to 2013. Patient(s): Patients undergoing the first fresh autologous ART cycle using either donor or partner sperm. Intervention(s): None. Main Outcome Measure(s): Miscarriage, preterm birth, low birthweight rates. Results: A total of 134,710 fresh autologous ART cycles were evaluated from the SART CORS database. Following exclusion criteria and after restricting to the first cycle, 2,123 donor sperm and 42,799 partner sperm ART cycles were included in the final analyses. After adjusting for all confounding variables (including maternal age, race, body mass index, smoking status, gravidity, history of preterm birth, highest follicle stimulating hormone count, blastocyst transfer percentage, total embryo transferred, and etiology of infertility), no statistically significant differences in miscarriage rates, preterm births, very preterm births, low birthweight, and very low birthweight were observed. Birthweight was significantly lower in the partner sperm group than in the donor sperm group (3,292 ± 601 and 3,233 ± 592 g in donor and partner sperm groups, respectively, adjusted P value 0.003); however, this small absolute difference (adjusted effect estimate 42 g, 95% CI 14.7–70.9) does not carry clinical significance. Conclusions: The use of donor sperm in fresh autologous ART cycles was not associated with increased miscarriage, preterm births, or low birthweights, as compared to cycles using partner sperm. This information can be used in patient counseling to reassure patients using donor sperm in ART cycles.

Original languageEnglish (US)
Pages (from-to)1285-1289
Number of pages5
JournalFertility and Sterility
Volume110
Issue number7
DOIs
StatePublished - Dec 1 2018

Fingerprint

Assisted Reproductive Techniques
Spermatozoa
Tissue Donors
Premature Birth
Spontaneous Abortion
Databases
Gravidity
Confounding Factors (Epidemiology)
Embryo Transfer
Maternal Age
Follicle Stimulating Hormone
Infertility
Counseling
Body Mass Index
Cohort Studies
Embryonic Structures
Smoking
Outcome Assessment (Health Care)

Keywords

  • ART cycle
  • Donor sperm
  • partner sperm
  • paternal antigens
  • perinatal outcomes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

The impact of using donor sperm in assisted reproductive technology cycles on perinatal outcomes. / Yu, Bo; Fritz, Rani; Xie, Xianhong; Negassa, Abdissa; Jindal, Sangita K.; Vega, Mario; Buyuk, Erkan.

In: Fertility and Sterility, Vol. 110, No. 7, 01.12.2018, p. 1285-1289.

Research output: Contribution to journalArticle

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abstract = "Objective: To assess the impact of using donor sperm in assisted reproductive technology (ART) cycles on perinatal outcomes. Design: Historical cohort study. Setting: US national database from the Society of Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) from 2012 to 2013. Patient(s): Patients undergoing the first fresh autologous ART cycle using either donor or partner sperm. Intervention(s): None. Main Outcome Measure(s): Miscarriage, preterm birth, low birthweight rates. Results: A total of 134,710 fresh autologous ART cycles were evaluated from the SART CORS database. Following exclusion criteria and after restricting to the first cycle, 2,123 donor sperm and 42,799 partner sperm ART cycles were included in the final analyses. After adjusting for all confounding variables (including maternal age, race, body mass index, smoking status, gravidity, history of preterm birth, highest follicle stimulating hormone count, blastocyst transfer percentage, total embryo transferred, and etiology of infertility), no statistically significant differences in miscarriage rates, preterm births, very preterm births, low birthweight, and very low birthweight were observed. Birthweight was significantly lower in the partner sperm group than in the donor sperm group (3,292 ± 601 and 3,233 ± 592 g in donor and partner sperm groups, respectively, adjusted P value 0.003); however, this small absolute difference (adjusted effect estimate 42 g, 95{\%} CI 14.7–70.9) does not carry clinical significance. Conclusions: The use of donor sperm in fresh autologous ART cycles was not associated with increased miscarriage, preterm births, or low birthweights, as compared to cycles using partner sperm. This information can be used in patient counseling to reassure patients using donor sperm in ART cycles.",
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