“The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design” – Meeting report

Cesar Boggiano, Katrin Eichelberg, Lakshmi Ramachandra, Jaqueline Shea, Lalita Ramakrishnan, Samuel Behar, Joel D. Ernst, Steven A. Porcelli, Markus Maeurer, Hardy Kornfeld

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Tuberculosis (TB) is the major cause of death from infectious diseases around the world, particularly in HIV infected individuals. TB vaccine design and development have been focused on improving Bacille Calmette-Guérin (BCG) and evaluating recombinant and viral vector expressed Mycobacterium tuberculosis (Mtb) proteins, for boosting BCG-primed immunity, but these approaches have not yet yielded significant improvements over the modest effects of BCG in protecting against infection or disease. On March 7–8, 2016, the National Institute of Allergy and Infectious Diseases (NIAID) convened a workshop on “The Impact of Mtb Immune Evasion on Protective Immunity: Implications for TB Vaccine Design” with the goal of defining immune mechanisms that could be targeted through novel research approaches, to inform vaccine design and immune therapeutic interventions for prevention of TB. The workshop addressed early infection events, the impact of Mtb evolution on the development and maintenance of an adaptive immune response, and the factors that influence protection against and progression to active disease. Scientific gaps and areas of study to revitalize and accelerate TB vaccine design were discussed and prioritized. These included a comprehensive evaluation of innate and Mtb–specific adaptive immune responses in the lung at different stages of disease; determining the role of B cells and antibodies (Abs) during Mtb infection; development of better assays to measure Mtb burden following exposure, infection, during latency and after treatment, and approaches to improving current animal models to study Mtb immunogenicity, TB disease and transmission.

Original languageEnglish (US)
Pages (from-to)3433-3440
Number of pages8
JournalVaccine
Volume35
Issue number27
DOIs
StatePublished - Jun 14 2017

Keywords

  • Immune evasion
  • Mycobacterium tuberculosis
  • Tuberculosis
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Boggiano, C., Eichelberg, K., Ramachandra, L., Shea, J., Ramakrishnan, L., Behar, S., Ernst, J. D., Porcelli, S. A., Maeurer, M., & Kornfeld, H. (2017). “The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design” – Meeting report. Vaccine, 35(27), 3433-3440. https://doi.org/10.1016/j.vaccine.2017.04.007