The impact of metal artifacts on IMRT dose distributions in TCP and NTCP

Yusung Kim, Wolfgang A. Tome

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Purpose: To investigate the effects of distorted head-and-neck (H&N) IMRT dose distributions (hot and cold spots) on normal tissue complication probability (NTCP) and tumor control probability (TCP) due to dental-metal artifacts. Methods: Five patients’ IMRT treatment plans have been analyzed, employing five different planning image data-sets: (a) uncorrected (UC); (b) homogeneous uncorrected (HUC); (c) sinogram completion corrected (SCC); (d) minimum-valuecorrected (MVC); and (e) streak-artifact-reduction including minimum-value-correction (SAR-MVC), that has been taken as the reference data set. The effects on NTCP and TCP were evaluated using the Lyman-NTCP model and the Logistic TCP model, respectively. Results: When compared to the predicted NTCP using the reference data set, the treatment plan based on the original CT data-set (UC) yielded an increase of 3.2% and 2.0% in NTCP for the spared parotid gland and the spinal cord. While the treatment plans based on the MVC CT data set NTCP increased by 1.1% and 0.1% for the spared parotid and the spinal cord. In addition, the MVC correction method showed reduced ΔTCP (MVC: 0.6% vs. UC: 1.3%) with respect to that of the reference CT data set. Conclusion: Our results indicate that the presence of dental- metal-artifacts in H&N planning CT data sets has an impact on the estimates of TCP and NTCP. In particular dentalmetal- artifacts lead to an increase in NTCP for the spared parotid and a slight decrease in TCP for TV.

Original languageEnglish (US)
Title of host publicationIFMBE Proceedings
PublisherSpringer Verlag
Pages1750-1753
Number of pages4
Volume14
Edition1
Publication statusPublished - 2007
Externally publishedYes
Event10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of
Duration: Aug 27 2006Sep 1 2006

Other

Other10th World Congress on Medical Physics and Biomedical Engineering, WC 2006
CountryKorea, Republic of
CitySeoul
Period8/27/069/1/06

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Keywords

  • Head and neck
  • Metal artifacts
  • NTCP
  • TCP
  • Treatment planning

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Kim, Y., & Tome, W. A. (2007). The impact of metal artifacts on IMRT dose distributions in TCP and NTCP. In IFMBE Proceedings (1 ed., Vol. 14, pp. 1750-1753). Springer Verlag.