TY - JOUR
T1 - The impact of height on the risk of atrial fibrillation
T2 - The Cardiovascular Health Study
AU - Rosenberg, Michael A.
AU - Patton, Kristen K.
AU - Sotoodehnia, Nona
AU - Karas, Maria G.
AU - Kizer, Jorge R.
AU - Zimetbaum, Peter J.
AU - Chang, James D.
AU - Siscovick, David
AU - Gottdiener, John S.
AU - Kronmal, Richard A.
AU - Heckbert, Susan R.
AU - Mukamal, Kenneth J.
N1 - Funding Information:
The research reported in this article was supported by contracts N01-HC-85239, N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, and grantsHL094555, HL080295, and HL068986 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided through AG-023629, AG-15928, AG-20098, and AG-027058 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm.
PY - 2012/11
Y1 - 2012/11
N2 - AimsAtrial fibrillation (AF) is the most common sustained arrhythmia. Increased body size has been associated with AF, but the relationship is not well understood. In this study, we examined the effect of increased height on the risk of AF and explore potential mediators and implications for clinical practice.Methods and resultsWe examined data from 5860 individuals taking part in the Cardiovascular Health Study, a cohort study of older US adults followed for a median of 13.6 (women) and 10.3 years (men). Multivariate linear models and age-stratified Cox proportional hazards and risk models were used, with focus on the effect of height on both prevalent and incident AF. Among 684 (22.6) and 568 (27.1) incident cases in women and men, respectively, greater height was significantly associated with AF risk [hazard ratio (HR) women per 10 cm 1.32, confidence interval (CI) 1.16-1.50, P < 0.0001; HRmen per 10 cm 1.26, CI 1.11-1.44, P < 0.0001]. The association was such that the incremental risk from sex was completely attenuated by the inclusion of height (for men, HR 1.48, CI 1.32-1.65, without height, and HR 0.94, CI 0.85-1.20, with height included). Inclusion of height in the Framingham model for incident AF improved discrimination. In sequential models, however, we found minimal attenuation of the risk estimates for AF with adjustment for left ventricular (LV) mass and left atrial (LA) dimension. The associations of LA and LV size measurements with AF risk were weakened when indexed to height.ConclusionIndependent from sex, increased height is significantly associated with the risk of AF.
AB - AimsAtrial fibrillation (AF) is the most common sustained arrhythmia. Increased body size has been associated with AF, but the relationship is not well understood. In this study, we examined the effect of increased height on the risk of AF and explore potential mediators and implications for clinical practice.Methods and resultsWe examined data from 5860 individuals taking part in the Cardiovascular Health Study, a cohort study of older US adults followed for a median of 13.6 (women) and 10.3 years (men). Multivariate linear models and age-stratified Cox proportional hazards and risk models were used, with focus on the effect of height on both prevalent and incident AF. Among 684 (22.6) and 568 (27.1) incident cases in women and men, respectively, greater height was significantly associated with AF risk [hazard ratio (HR) women per 10 cm 1.32, confidence interval (CI) 1.16-1.50, P < 0.0001; HRmen per 10 cm 1.26, CI 1.11-1.44, P < 0.0001]. The association was such that the incremental risk from sex was completely attenuated by the inclusion of height (for men, HR 1.48, CI 1.32-1.65, without height, and HR 0.94, CI 0.85-1.20, with height included). Inclusion of height in the Framingham model for incident AF improved discrimination. In sequential models, however, we found minimal attenuation of the risk estimates for AF with adjustment for left ventricular (LV) mass and left atrial (LA) dimension. The associations of LA and LV size measurements with AF risk were weakened when indexed to height.ConclusionIndependent from sex, increased height is significantly associated with the risk of AF.
KW - Atrial fibrillation
KW - Cardiovascular risk factors
KW - Echocardiography
KW - Risk prediction
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U2 - 10.1093/eurheartj/ehs301
DO - 10.1093/eurheartj/ehs301
M3 - Article
C2 - 22977225
AN - SCOPUS:84868516435
SN - 0195-668X
VL - 33
SP - 2709
EP - 2717
JO - European heart journal
JF - European heart journal
IS - 21
ER -