The impact of height on the risk of atrial fibrillation: The Cardiovascular Health Study

Michael A. Rosenberg, Kristen K. Patton, Nona Sotoodehnia, Maria G. Karas, Jorge R. Kizer, Peter J. Zimetbaum, James D. Chang, David Siscovick, John S. Gottdiener, Richard A. Kronmal, Susan R. Heckbert, Kenneth J. Mukamal

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

AimsAtrial fibrillation (AF) is the most common sustained arrhythmia. Increased body size has been associated with AF, but the relationship is not well understood. In this study, we examined the effect of increased height on the risk of AF and explore potential mediators and implications for clinical practice.Methods and resultsWe examined data from 5860 individuals taking part in the Cardiovascular Health Study, a cohort study of older US adults followed for a median of 13.6 (women) and 10.3 years (men). Multivariate linear models and age-stratified Cox proportional hazards and risk models were used, with focus on the effect of height on both prevalent and incident AF. Among 684 (22.6) and 568 (27.1) incident cases in women and men, respectively, greater height was significantly associated with AF risk [hazard ratio (HR) women per 10 cm 1.32, confidence interval (CI) 1.16-1.50, P < 0.0001; HRmen per 10 cm 1.26, CI 1.11-1.44, P < 0.0001]. The association was such that the incremental risk from sex was completely attenuated by the inclusion of height (for men, HR 1.48, CI 1.32-1.65, without height, and HR 0.94, CI 0.85-1.20, with height included). Inclusion of height in the Framingham model for incident AF improved discrimination. In sequential models, however, we found minimal attenuation of the risk estimates for AF with adjustment for left ventricular (LV) mass and left atrial (LA) dimension. The associations of LA and LV size measurements with AF risk were weakened when indexed to height.ConclusionIndependent from sex, increased height is significantly associated with the risk of AF.

Original languageEnglish (US)
Pages (from-to)2709-2717
Number of pages9
JournalEuropean heart journal
Volume33
Issue number21
DOIs
StatePublished - Nov 2012

Keywords

  • Atrial fibrillation
  • Cardiovascular risk factors
  • Echocardiography
  • Risk prediction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Rosenberg, M. A., Patton, K. K., Sotoodehnia, N., Karas, M. G., Kizer, J. R., Zimetbaum, P. J., Chang, J. D., Siscovick, D., Gottdiener, J. S., Kronmal, R. A., Heckbert, S. R., & Mukamal, K. J. (2012). The impact of height on the risk of atrial fibrillation: The Cardiovascular Health Study. European heart journal, 33(21), 2709-2717. https://doi.org/10.1093/eurheartj/ehs301