The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group

on behalf of the Neonatal Kidney Collaborative

doi:10.1038/s41390-019-0579-1

The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group

on behalf of the Neonatal Kidney Collaborative

Pediatrics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study. Methods: Retrospective analysis of infants <36 weeks’ gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight. Outcome: Mechanical ventilation (MV) at postnatal day 7. Results: One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: −2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10–1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07–1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06–1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12–0.35). Conclusions: Positive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.

Original language	English (US)
Pages (from-to)	550-557
Number of pages	8
Journal	Pediatric Research
Volume	87
Issue number	3
DOIs	https://doi.org/10.1038/s41390-019-0579-1
State	Published - Feb 1 2020

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1038/s41390-019-0579-1

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@article{d4ab38dc0960439384a827acc4af2d80,

title = "The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group",

abstract = "Background: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study. Methods: Retrospective analysis of infants <36 weeks{\textquoteright} gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight. Outcome: Mechanical ventilation (MV) at postnatal day 7. Results: One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: −2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10–1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07–1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06–1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12–0.35). Conclusions: Positive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.",

author = "{on behalf of the Neonatal Kidney Collaborative} and Selewski, {David T.} and Gist, {Katja M.} and Nathan, {Amy T.} and Goldstein, {Stuart L.} and Boohaker, {Louis J.} and Ayse Akcan-Arikan and Bonachea, {Elizabeth M.} and Mina Hanna and Catherine Joseph and Mahan, {John D.} and Cherry Mammen and Arwa Nada and Kimberly Reidy and Amy Staples and Pia Wintermark and Russell Griffin and Askenazi, {David J.} and Ronnie Guillet and Namasivayam Ambalavanan and Subrata Sarkar and Alison Kent and Jeffery Fletcher and Abitbol, {Carolyn L.} and Marissa DeFreitas and Shahnaz Duara and Charlton, {Jennifer R.} and Swanson, {Jonathan R.} and Carl D{\textquoteright}Angio and Ayesa Mian and Erin Rademacher and Mhanna, {Maroun J.} and Rupesh Raina and Deepak Kumar and Jetton, {Jennifer G.} and Brophy, {Patrick D.} and Colaizy, {Tarah T.} and Klein, {Jonathan M.} and Rhee, {Christopher J.} and Kupferman, {Juan C.} and Alok Bhutada and Shantanu Rastogi and Susan Ingraham and Cole, {F. Sessions} and Davis, {T. Keefe} and Lawrence Milner and Alexandra Smith and Mamta Fuloria and Kaskel, {Frederick J.} and Soranno, {Danielle E.} and Jason Gien",

note = "Funding Information: The authors would also like to thank the outstanding work of the following clinical research personnel and colleagues for their involvement in AWAKEN: Ariana Aimani, Samantha Kronish, Ana Palijan, MD, Michael Pizzi—Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada; Laila Ajour, BS, Julia Wrona, BS —University of Colorado, Children's Hospital Colorado, Aurora, CO; Melissa Bowman, RN—University of Rochester, Rochester, NY; Teresa Cano, RN, Marta G. Galarza, MD, Wendy Glaberson, MD, Aura Arenas Morales, MD, Denisse, Cristina Pareja Valarezo, MD—Holtz Children's Hospital, University of Miami, Miami, FL; Sarah Cashman, BS, Madeleine Stead, BS—University of Iowa Children{\textquoteright}s Hospital, Iowa City, IA; Jonathan Davis, MD, Julie Nicoletta, MD—Floating Hospital for Children at Tufts Medical Center, Tufts University School of Medicine, Boston, MA; Alanna DeMello—British Columbia Children's Hospital, Vancouver, BC, Canada; Lynn Dill, RN—University of Alabama at Birmingham, Birmingham, AL; Ellen Guthrie, RN—MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH; Nicholas L. Harris, BS, Susan M. Hieber, MSQM—C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI; Katherine Huang, Rosa Waters—University of Virginia Children{\textquoteright}s Hospital, Charlottesville, VA; Judd Jacobs, Ryan Knox, BS, Hilary Pitner, MS, Tara Terrell—Cincinnati Children{\textquoteright}s Hospital Medical, Center, Cincinnati, OH; Nilima Jawale, MD—Maimonides Medical Center, Brooklyn, NY; Emily Kane—Australian National University, Canberra, ACT, Australia; Vijay Kher, DM, Puneet Sodhi, MBBS—Medanta Kidney Institute, The Medicity Hospital, Gurgaon, Haryana, India; Grace Mele—New York College of Osteopathic Medicine, Westbury, NY; Patricia Mele, DNP—Stony Brook Children{\textquoteright}s Hospital, Stony Brook, NY; Charity Njoku, Tennille Paulsen, Sadia Zubair—Texas Children{\textquoteright}s Hospital, Baylor College of Medicine, Houston, TX; Emily Pao—University of Washington, Seattle Children's Hospital, Seattle, WA; Becky Selman RN, Michele Spear, CCRC—University of New Mexico Health Sciences Center, Albuquerque, NM; Melissa Vega, PA-C—The Children{\textquoteright}s Hospital at Montefiore, Bronx, NY, USA); Leslie Walther, RN—Washington University, St. Louis, MO. Cincinnati Children{\textquoteright}s Hospital Center for Acute Care Nephrology provided funding to create and maintain the AWAKEN Medidata Rave electronic database. The Pediatric and Infant Center for Acute Nephrology (PICAN) provided support for web meetings, for the NKC steering committee annual meeting at the University of Alabama at Birmingham (UAB), as well as support for some of the AWAKEN investigators at UAB (L.J.B., R. Griffin). PICAN is part of the Department of Pediatrics at the University of Alabama at Birmingham (UAB) and is funded by Children{\textquoteright}s of Alabama Hospital, the Department of Pediatrics, UAB School of Medicine, and UAB{\textquoteright}s Center for Clinical and Translational Sciences (CCTS, NIH grant UL1TR001417). Finally, the AWAKEN study at the University of New Mexico was supported by the Clinical and Translational Science Center (CTSC, NIH grant UL1TR001449) and by the University of Iowa Institute for Clinical and Translational Science (U54TR001356). C.L.A. was supported by the Micah Batchelor Foundation. A.-A.A. and C.J.R. were supported by the Section of Pediatric Nephrology, Department of Pediatrics, Texas Children{\textquoteright}s Hospital. J.R.C. and J.R.S. were supported by a grant from 100 Women Who Care. F.S.C. and K.T.D. were supported by the Edward Mallinckrodt Department of Pediatrics at Washington University School of Medicine. J.F. and A.K. supported by the Canberra Hospital Private Practice Fund. R.G. and E.R. were supported by the Department of Pediatrics, Golisano Children{\textquoteright}s Hospital, University of Rochester. P.E.R. was supported by R01 HL-102497, R01 DK 49419. S.S. and D.T.S. were supported by the Department of Pediatrics & Communicable Disease, C.S. Mott Children{\textquoteright}s Hospital, University of Michigan. S.S. and R.W. were supported by Stony Brook Children{\textquoteright}s Hospital Department of Pediatrics funding. Funding sources for this study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Funding Information: Competing interests: D.J.A. serves on the speaker board for Baxter (Baxter, USA) and the Acute Kidney Injury (AKI) Foundation (Cincinnati, OH, USA); he also receives grant funding for studies not related to this manuscript from National Institutes of Health— National Institutes of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK (R01 DK103608) and NIH-FDA (R01 FD005092)). K.M.G. is a consultant for BioPorto. The other authors declare no competing interests.",

year = "2020",

month = feb,

day = "1",

doi = "10.1038/s41390-019-0579-1",

language = "English (US)",

volume = "87",

pages = "550--557",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - The impact of fluid balance on outcomes in premature neonates

T2 - a report from the AWAKEN study group

AU - on behalf of the Neonatal Kidney Collaborative

AU - Selewski, David T.

AU - Gist, Katja M.

AU - Nathan, Amy T.

AU - Goldstein, Stuart L.

AU - Boohaker, Louis J.

AU - Akcan-Arikan, Ayse

AU - Bonachea, Elizabeth M.

AU - Hanna, Mina

AU - Joseph, Catherine

AU - Mahan, John D.

AU - Mammen, Cherry

AU - Nada, Arwa

AU - Reidy, Kimberly

AU - Staples, Amy

AU - Wintermark, Pia

AU - Griffin, Russell

AU - Askenazi, David J.

AU - Guillet, Ronnie

AU - Ambalavanan, Namasivayam

AU - Sarkar, Subrata

AU - Kent, Alison

AU - Fletcher, Jeffery

AU - Abitbol, Carolyn L.

AU - DeFreitas, Marissa

AU - Duara, Shahnaz

AU - Charlton, Jennifer R.

AU - Swanson, Jonathan R.

AU - D’Angio, Carl

AU - Mian, Ayesa

AU - Rademacher, Erin

AU - Mhanna, Maroun J.

AU - Raina, Rupesh

AU - Kumar, Deepak

AU - Jetton, Jennifer G.

AU - Brophy, Patrick D.

AU - Colaizy, Tarah T.

AU - Klein, Jonathan M.

AU - Rhee, Christopher J.

AU - Kupferman, Juan C.

AU - Bhutada, Alok

AU - Rastogi, Shantanu

AU - Ingraham, Susan

AU - Cole, F. Sessions

AU - Davis, T. Keefe

AU - Milner, Lawrence

AU - Smith, Alexandra

AU - Fuloria, Mamta

AU - Kaskel, Frederick J.

AU - Soranno, Danielle E.

AU - Gien, Jason

N1 - Funding Information: The authors would also like to thank the outstanding work of the following clinical research personnel and colleagues for their involvement in AWAKEN: Ariana Aimani, Samantha Kronish, Ana Palijan, MD, Michael Pizzi—Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada; Laila Ajour, BS, Julia Wrona, BS —University of Colorado, Children's Hospital Colorado, Aurora, CO; Melissa Bowman, RN—University of Rochester, Rochester, NY; Teresa Cano, RN, Marta G. Galarza, MD, Wendy Glaberson, MD, Aura Arenas Morales, MD, Denisse, Cristina Pareja Valarezo, MD—Holtz Children's Hospital, University of Miami, Miami, FL; Sarah Cashman, BS, Madeleine Stead, BS—University of Iowa Children’s Hospital, Iowa City, IA; Jonathan Davis, MD, Julie Nicoletta, MD—Floating Hospital for Children at Tufts Medical Center, Tufts University School of Medicine, Boston, MA; Alanna DeMello—British Columbia Children's Hospital, Vancouver, BC, Canada; Lynn Dill, RN—University of Alabama at Birmingham, Birmingham, AL; Ellen Guthrie, RN—MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH; Nicholas L. Harris, BS, Susan M. Hieber, MSQM—C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI; Katherine Huang, Rosa Waters—University of Virginia Children’s Hospital, Charlottesville, VA; Judd Jacobs, Ryan Knox, BS, Hilary Pitner, MS, Tara Terrell—Cincinnati Children’s Hospital Medical, Center, Cincinnati, OH; Nilima Jawale, MD—Maimonides Medical Center, Brooklyn, NY; Emily Kane—Australian National University, Canberra, ACT, Australia; Vijay Kher, DM, Puneet Sodhi, MBBS—Medanta Kidney Institute, The Medicity Hospital, Gurgaon, Haryana, India; Grace Mele—New York College of Osteopathic Medicine, Westbury, NY; Patricia Mele, DNP—Stony Brook Children’s Hospital, Stony Brook, NY; Charity Njoku, Tennille Paulsen, Sadia Zubair—Texas Children’s Hospital, Baylor College of Medicine, Houston, TX; Emily Pao—University of Washington, Seattle Children's Hospital, Seattle, WA; Becky Selman RN, Michele Spear, CCRC—University of New Mexico Health Sciences Center, Albuquerque, NM; Melissa Vega, PA-C—The Children’s Hospital at Montefiore, Bronx, NY, USA); Leslie Walther, RN—Washington University, St. Louis, MO. Cincinnati Children’s Hospital Center for Acute Care Nephrology provided funding to create and maintain the AWAKEN Medidata Rave electronic database. The Pediatric and Infant Center for Acute Nephrology (PICAN) provided support for web meetings, for the NKC steering committee annual meeting at the University of Alabama at Birmingham (UAB), as well as support for some of the AWAKEN investigators at UAB (L.J.B., R. Griffin). PICAN is part of the Department of Pediatrics at the University of Alabama at Birmingham (UAB) and is funded by Children’s of Alabama Hospital, the Department of Pediatrics, UAB School of Medicine, and UAB’s Center for Clinical and Translational Sciences (CCTS, NIH grant UL1TR001417). Finally, the AWAKEN study at the University of New Mexico was supported by the Clinical and Translational Science Center (CTSC, NIH grant UL1TR001449) and by the University of Iowa Institute for Clinical and Translational Science (U54TR001356). C.L.A. was supported by the Micah Batchelor Foundation. A.-A.A. and C.J.R. were supported by the Section of Pediatric Nephrology, Department of Pediatrics, Texas Children’s Hospital. J.R.C. and J.R.S. were supported by a grant from 100 Women Who Care. F.S.C. and K.T.D. were supported by the Edward Mallinckrodt Department of Pediatrics at Washington University School of Medicine. J.F. and A.K. supported by the Canberra Hospital Private Practice Fund. R.G. and E.R. were supported by the Department of Pediatrics, Golisano Children’s Hospital, University of Rochester. P.E.R. was supported by R01 HL-102497, R01 DK 49419. S.S. and D.T.S. were supported by the Department of Pediatrics & Communicable Disease, C.S. Mott Children’s Hospital, University of Michigan. S.S. and R.W. were supported by Stony Brook Children’s Hospital Department of Pediatrics funding. Funding sources for this study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Funding Information: Competing interests: D.J.A. serves on the speaker board for Baxter (Baxter, USA) and the Acute Kidney Injury (AKI) Foundation (Cincinnati, OH, USA); he also receives grant funding for studies not related to this manuscript from National Institutes of Health— National Institutes of Diabetes and Digestive and Kidney Diseases (NIH-NIDDK (R01 DK103608) and NIH-FDA (R01 FD005092)). K.M.G. is a consultant for BioPorto. The other authors declare no competing interests.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Background: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study. Methods: Retrospective analysis of infants <36 weeks’ gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight. Outcome: Mechanical ventilation (MV) at postnatal day 7. Results: One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: −2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10–1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07–1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06–1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12–0.35). Conclusions: Positive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.

AB - Background: We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study. Methods: Retrospective analysis of infants <36 weeks’ gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight. Outcome: Mechanical ventilation (MV) at postnatal day 7. Results: One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: −2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10–1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07–1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06–1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12–0.35). Conclusions: Positive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.

UR - http://www.scopus.com/inward/record.url?scp=85074366989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074366989&partnerID=8YFLogxK

U2 - 10.1038/s41390-019-0579-1

DO - 10.1038/s41390-019-0579-1

M3 - Article

C2 - 31537009

AN - SCOPUS:85074366989

VL - 87

SP - 550

EP - 557

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 3

ER -