The impact of birth weight on cardiovascular disease risk in the Women's Health Initiative

C. J. Smith, K. K. Ryckman, V. M. Barnabei, B. V. Howard, Carmen R. Isasi, G. E. Sarto, S. E. Tom, L. V. Van Horn, R. B. Wallace, J. G. Robinson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and aims: Cardiovascular disease (CVD) is among the leading causes of morbidity and mortality worldwide. Traditional risk factors predict 75-80% of an individual's risk of incident CVD. However, the role of early life experiences in future disease risk is gaining attention. The Barker hypothesis proposes fetal origins of adult disease, with consistent evidence demonstrating the deleterious consequences of birth weight outside the normal range. In this study, we investigate the role of birth weight in CVD risk prediction. Methods and results: The Women's Health Initiative (WHI) represents a large national cohort of post-menopausal women with 63,815 participants included in this analysis. Univariable proportional hazards regression analyses evaluated the association of 4 self-reported birth weight categories against 3 CVD outcome definitions, which included indicators of coronary heart disease, ischemic stroke, coronary revascularization, carotid artery disease and peripheral arterial disease. The role of birth weight was also evaluated for prediction of CVD events in the presence of traditional risk factors using 3 existing CVD risk prediction equations: one body mass index (BMI)-based and two laboratory-based models. Low birth weight (LBW) (

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Women's Health
Birth Weight
Cardiovascular Diseases
Carotid Artery Diseases
Peripheral Arterial Disease
Life Change Events
Low Birth Weight Infant
Coronary Disease
Reference Values
Body Mass Index
Stroke
Regression Analysis
Morbidity
Mortality

Keywords

  • Barker hypothesis
  • Life course epidemiology
  • Metabolic syndrome
  • Proportional hazards model
  • Risk prediction
  • Self-reported birth weight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

The impact of birth weight on cardiovascular disease risk in the Women's Health Initiative. / Smith, C. J.; Ryckman, K. K.; Barnabei, V. M.; Howard, B. V.; Isasi, Carmen R.; Sarto, G. E.; Tom, S. E.; Van Horn, L. V.; Wallace, R. B.; Robinson, J. G.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 26, No. 3, 01.03.2016, p. 239-245.

Research output: Contribution to journalArticle

Smith, CJ, Ryckman, KK, Barnabei, VM, Howard, BV, Isasi, CR, Sarto, GE, Tom, SE, Van Horn, LV, Wallace, RB & Robinson, JG 2016, 'The impact of birth weight on cardiovascular disease risk in the Women's Health Initiative', Nutrition, Metabolism and Cardiovascular Diseases, vol. 26, no. 3, pp. 239-245. https://doi.org/10.1016/j.numecd.2015.10.015
Smith, C. J. ; Ryckman, K. K. ; Barnabei, V. M. ; Howard, B. V. ; Isasi, Carmen R. ; Sarto, G. E. ; Tom, S. E. ; Van Horn, L. V. ; Wallace, R. B. ; Robinson, J. G. / The impact of birth weight on cardiovascular disease risk in the Women's Health Initiative. In: Nutrition, Metabolism and Cardiovascular Diseases. 2016 ; Vol. 26, No. 3. pp. 239-245.
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