The immunological aspects of latency in tuberculosis

John Chan, JoAnne Flynn

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

A unique feature of Mycobacterium tuberculosis is its ability to exist in the granuloma of an asymptomatic host in a latent state that can subsequently reactivate to cause active disease. The latent state of infection poses a major obstacle to eradicating tuberculosis. In latent tuberculosis, the host immune response is capable of controlling the infection and yet falls short of eradicating the pathogen. That the host immune response contributes to the maintenance of latent tuberculous infection is supported by the observation that certain immunodeficient states, including those associated with the human immunodeficiency virus and tumor necrosis factor neutralization therapy, are associated with increased risks for developing reactivation disease. Latent tuberculosis is the product of a complex set of interactions between M. tuberculosis and the host immune response. The molecular basis for the persistence phenotype of M. tuberculosis and the pertinent host immune mechanisms that contribute to the maintenance of tuberculous latency are just beginning to be understood. This review discusses the interactions between M. tuberculosis and the macrophage, the primary host cell that the tubercle bacillus parasitizes.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalClinical Immunology
Volume110
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Mycobacterium tuberculosis
Tuberculosis
Latent Tuberculosis
Infection
Maintenance
Granuloma
Bacillus
Tumor Necrosis Factor-alpha
Macrophages
HIV
Phenotype
Therapeutics

Keywords

  • Immune response
  • Infection
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The immunological aspects of latency in tuberculosis. / Chan, John; Flynn, JoAnne.

In: Clinical Immunology, Vol. 110, No. 1, 01.2004, p. 2-12.

Research output: Contribution to journalArticle

Chan, John ; Flynn, JoAnne. / The immunological aspects of latency in tuberculosis. In: Clinical Immunology. 2004 ; Vol. 110, No. 1. pp. 2-12.
@article{08f0d913867744bcb1ce2b5034fa041b,
title = "The immunological aspects of latency in tuberculosis",
abstract = "A unique feature of Mycobacterium tuberculosis is its ability to exist in the granuloma of an asymptomatic host in a latent state that can subsequently reactivate to cause active disease. The latent state of infection poses a major obstacle to eradicating tuberculosis. In latent tuberculosis, the host immune response is capable of controlling the infection and yet falls short of eradicating the pathogen. That the host immune response contributes to the maintenance of latent tuberculous infection is supported by the observation that certain immunodeficient states, including those associated with the human immunodeficiency virus and tumor necrosis factor neutralization therapy, are associated with increased risks for developing reactivation disease. Latent tuberculosis is the product of a complex set of interactions between M. tuberculosis and the host immune response. The molecular basis for the persistence phenotype of M. tuberculosis and the pertinent host immune mechanisms that contribute to the maintenance of tuberculous latency are just beginning to be understood. This review discusses the interactions between M. tuberculosis and the macrophage, the primary host cell that the tubercle bacillus parasitizes.",
keywords = "Immune response, Infection, Mycobacterium tuberculosis",
author = "John Chan and JoAnne Flynn",
year = "2004",
month = "1",
doi = "10.1016/S1521-6616(03)00210-9",
language = "English (US)",
volume = "110",
pages = "2--12",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The immunological aspects of latency in tuberculosis

AU - Chan, John

AU - Flynn, JoAnne

PY - 2004/1

Y1 - 2004/1

N2 - A unique feature of Mycobacterium tuberculosis is its ability to exist in the granuloma of an asymptomatic host in a latent state that can subsequently reactivate to cause active disease. The latent state of infection poses a major obstacle to eradicating tuberculosis. In latent tuberculosis, the host immune response is capable of controlling the infection and yet falls short of eradicating the pathogen. That the host immune response contributes to the maintenance of latent tuberculous infection is supported by the observation that certain immunodeficient states, including those associated with the human immunodeficiency virus and tumor necrosis factor neutralization therapy, are associated with increased risks for developing reactivation disease. Latent tuberculosis is the product of a complex set of interactions between M. tuberculosis and the host immune response. The molecular basis for the persistence phenotype of M. tuberculosis and the pertinent host immune mechanisms that contribute to the maintenance of tuberculous latency are just beginning to be understood. This review discusses the interactions between M. tuberculosis and the macrophage, the primary host cell that the tubercle bacillus parasitizes.

AB - A unique feature of Mycobacterium tuberculosis is its ability to exist in the granuloma of an asymptomatic host in a latent state that can subsequently reactivate to cause active disease. The latent state of infection poses a major obstacle to eradicating tuberculosis. In latent tuberculosis, the host immune response is capable of controlling the infection and yet falls short of eradicating the pathogen. That the host immune response contributes to the maintenance of latent tuberculous infection is supported by the observation that certain immunodeficient states, including those associated with the human immunodeficiency virus and tumor necrosis factor neutralization therapy, are associated with increased risks for developing reactivation disease. Latent tuberculosis is the product of a complex set of interactions between M. tuberculosis and the host immune response. The molecular basis for the persistence phenotype of M. tuberculosis and the pertinent host immune mechanisms that contribute to the maintenance of tuberculous latency are just beginning to be understood. This review discusses the interactions between M. tuberculosis and the macrophage, the primary host cell that the tubercle bacillus parasitizes.

KW - Immune response

KW - Infection

KW - Mycobacterium tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=0842346271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842346271&partnerID=8YFLogxK

U2 - 10.1016/S1521-6616(03)00210-9

DO - 10.1016/S1521-6616(03)00210-9

M3 - Article

C2 - 14986673

AN - SCOPUS:0842346271

VL - 110

SP - 2

EP - 12

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 1

ER -