The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases

Rudolf Valenta, Steven Almo, Tanja Ball, Christiane Dolecek, Peter Steinberger, Sylvia Laffer, Petra Eibensteiner, Sabine Flicker, Susanne Vrtala, Susanne Spitzauer, Peter Valent, Stephan Denepoux, Dietrich Kraft, Jacques Banchereau, Serge Lebecque

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.

Original languageEnglish (US)
Pages (from-to)167-176
Number of pages10
JournalInternational Archives of Allergy and Immunology
Volume116
Issue number3
DOIs
StatePublished - Jul 1 1998

Keywords

  • Blocking antibody
  • Immunoglobulin E
  • Immunotherapy
  • Recombinant allergens
  • Type I allergy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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