The hypothalamus for whole-body physiology: from metabolism to aging

Tiemin Liu, Yong Xu, Chun Xia Yi, Qingchun Tong, Dongsheng Cai

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing brain dysfunction as a root cause for the epidemic of aging and obesity-related disorders. We also speculate key issues that need to be addressed on how to reveal relevant brain dysfunction that underlines the development of these disorders and diseases in order to develop new treatment strategies against these health problems.

Original languageEnglish (US)
JournalProtein and Cell
DOIs
StateAccepted/In press - 2021

Keywords

  • aging
  • hypothalamus
  • metabolism
  • neuron
  • obesity

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

Fingerprint

Dive into the research topics of 'The hypothalamus for whole-body physiology: from metabolism to aging'. Together they form a unique fingerprint.

Cite this