The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo

Ari A. Gershon, Jeremy Rudnick, Lobina Kalam, Kathryn Zimmerman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The development of the vertebrate nervous system depends upon striking a balance between differentiating neurons and neural progenitors in the early embryo. Our findings suggest that the homeodomain-containing gene Xdbx regulates this balance by maintaining neural progenitor populations within specific regions of the neuroectoderm. In posterior regions of the Xenopus embryo, Xdbx is expressed in a bilaterally symmetric stripe that lies at the middle of the mediolateral axis of the neural plate. This stripe of Xdbx expression overlaps the expression domain of the proneural basic/helix-loop-helix-containing gene, Xash3, and is juxtaposed to the expression domains of Xenopus Neurogenin related 1 and N-tubulin, markers of early neurogenesis in the embryo. Xdbx overexpression inhibits neuronal differentiation in the embryo and when co-injected with Xash3, Xdbx inhibits the ability of Xash3 to induce ectopic neurogenesis. One role of Xdbx during normal development may therefore be to restrict spatially neuronal differentiation within the neural plate, possibly by altering the neuronal differentiation function of Xash3.

Original languageEnglish (US)
Pages (from-to)2945-2954
Number of pages10
JournalDevelopment
Volume127
Issue number13
StatePublished - Jul 2000
Externally publishedYes

Fingerprint

Neural Plate
Embryonic Structures
Neurogenesis
Genes
Tubulin
Xenopus
Nervous System
Vertebrates
Neurons
Population

Keywords

  • Homeodomain
  • Neural progenitors
  • Neurogenesis
  • Xdbx
  • Xenopus

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Gershon, A. A., Rudnick, J., Kalam, L., & Zimmerman, K. (2000). The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo. Development, 127(13), 2945-2954.

The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo. / Gershon, Ari A.; Rudnick, Jeremy; Kalam, Lobina; Zimmerman, Kathryn.

In: Development, Vol. 127, No. 13, 07.2000, p. 2945-2954.

Research output: Contribution to journalArticle

Gershon, AA, Rudnick, J, Kalam, L & Zimmerman, K 2000, 'The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo', Development, vol. 127, no. 13, pp. 2945-2954.
Gershon AA, Rudnick J, Kalam L, Zimmerman K. The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo. Development. 2000 Jul;127(13):2945-2954.
Gershon, Ari A. ; Rudnick, Jeremy ; Kalam, Lobina ; Zimmerman, Kathryn. / The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo. In: Development. 2000 ; Vol. 127, No. 13. pp. 2945-2954.
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