The H*1 hematology analyzer. Its performance characteristics and value in the diagnosis of infectious disease

B. Wenz, M. A. Ramirez, Edward R. Burns

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The performance characteristics and the value of data provided by the H*1 Automated Blood Cell Analyzer in the diagnosis of infectious disease are assessed. Data produced by the machine are precise over a wide range of complete blood cell counts and differential white blood cell (WBC) parameters. It is capable of accurately quantifying WBCs greater than 4000/mm3 (4 x 109/L); red blood cells (RBCs), > 2.5 x 106/mm3 (2.5 x 1012/L); and platelets greater than 1 x 103/mm3 (1 x 109/L). There is good agreement between the neutrophils and lymphocytes quantified by the standard microscopic count and the automated system; however, cells that are generally present in low incidence, namely, monocytes, basophils, and eosinophils, are less well correlated. The microscopic band cell count provides the greatest test efficiency in the diagnosis of infection. None of the unique parameters generated by the H*1 differential analyzer proved to have neither a test efficiency nor a diagnostic index greater than that of the absolute WBC count in the diagnosis of infection. The 'left shift' in the leukocyte differential count as detected by the H*1 relates poorly to the presence of band neutrophils in the specimen. It is concluded that the state-of-the-art automated leukocyte differential count can dramatically reduce work-load, but offers no advantage over the traditional differential WBC count in the diagnosis of infectious disease. Its potential value in the diagnosis of other conditions, particularly hematologic diseases, and in the sequential monitoring of infections in individual patients were not addressed by the present study.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume111
Issue number6
StatePublished - 1987

Fingerprint

Hematology
Communicable Diseases
Leukocyte Count
Blood Cell Count
Neutrophils
Infection
Basophils
Hematologic Diseases
Workload
Eosinophils
Monocytes
Blood Cells
Leukocytes
Blood Platelets
Cell Count
Erythrocytes
Lymphocytes
Incidence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

The H*1 hematology analyzer. Its performance characteristics and value in the diagnosis of infectious disease. / Wenz, B.; Ramirez, M. A.; Burns, Edward R.

In: Archives of Pathology and Laboratory Medicine, Vol. 111, No. 6, 1987, p. 521-524.

Research output: Contribution to journalArticle

@article{cb3a86918d724988ade2ff69f886973e,
title = "The H*1 hematology analyzer. Its performance characteristics and value in the diagnosis of infectious disease",
abstract = "The performance characteristics and the value of data provided by the H*1 Automated Blood Cell Analyzer in the diagnosis of infectious disease are assessed. Data produced by the machine are precise over a wide range of complete blood cell counts and differential white blood cell (WBC) parameters. It is capable of accurately quantifying WBCs greater than 4000/mm3 (4 x 109/L); red blood cells (RBCs), > 2.5 x 106/mm3 (2.5 x 1012/L); and platelets greater than 1 x 103/mm3 (1 x 109/L). There is good agreement between the neutrophils and lymphocytes quantified by the standard microscopic count and the automated system; however, cells that are generally present in low incidence, namely, monocytes, basophils, and eosinophils, are less well correlated. The microscopic band cell count provides the greatest test efficiency in the diagnosis of infection. None of the unique parameters generated by the H*1 differential analyzer proved to have neither a test efficiency nor a diagnostic index greater than that of the absolute WBC count in the diagnosis of infection. The 'left shift' in the leukocyte differential count as detected by the H*1 relates poorly to the presence of band neutrophils in the specimen. It is concluded that the state-of-the-art automated leukocyte differential count can dramatically reduce work-load, but offers no advantage over the traditional differential WBC count in the diagnosis of infectious disease. Its potential value in the diagnosis of other conditions, particularly hematologic diseases, and in the sequential monitoring of infections in individual patients were not addressed by the present study.",
author = "B. Wenz and Ramirez, {M. A.} and Burns, {Edward R.}",
year = "1987",
language = "English (US)",
volume = "111",
pages = "521--524",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "6",

}

TY - JOUR

T1 - The H*1 hematology analyzer. Its performance characteristics and value in the diagnosis of infectious disease

AU - Wenz, B.

AU - Ramirez, M. A.

AU - Burns, Edward R.

PY - 1987

Y1 - 1987

N2 - The performance characteristics and the value of data provided by the H*1 Automated Blood Cell Analyzer in the diagnosis of infectious disease are assessed. Data produced by the machine are precise over a wide range of complete blood cell counts and differential white blood cell (WBC) parameters. It is capable of accurately quantifying WBCs greater than 4000/mm3 (4 x 109/L); red blood cells (RBCs), > 2.5 x 106/mm3 (2.5 x 1012/L); and platelets greater than 1 x 103/mm3 (1 x 109/L). There is good agreement between the neutrophils and lymphocytes quantified by the standard microscopic count and the automated system; however, cells that are generally present in low incidence, namely, monocytes, basophils, and eosinophils, are less well correlated. The microscopic band cell count provides the greatest test efficiency in the diagnosis of infection. None of the unique parameters generated by the H*1 differential analyzer proved to have neither a test efficiency nor a diagnostic index greater than that of the absolute WBC count in the diagnosis of infection. The 'left shift' in the leukocyte differential count as detected by the H*1 relates poorly to the presence of band neutrophils in the specimen. It is concluded that the state-of-the-art automated leukocyte differential count can dramatically reduce work-load, but offers no advantage over the traditional differential WBC count in the diagnosis of infectious disease. Its potential value in the diagnosis of other conditions, particularly hematologic diseases, and in the sequential monitoring of infections in individual patients were not addressed by the present study.

AB - The performance characteristics and the value of data provided by the H*1 Automated Blood Cell Analyzer in the diagnosis of infectious disease are assessed. Data produced by the machine are precise over a wide range of complete blood cell counts and differential white blood cell (WBC) parameters. It is capable of accurately quantifying WBCs greater than 4000/mm3 (4 x 109/L); red blood cells (RBCs), > 2.5 x 106/mm3 (2.5 x 1012/L); and platelets greater than 1 x 103/mm3 (1 x 109/L). There is good agreement between the neutrophils and lymphocytes quantified by the standard microscopic count and the automated system; however, cells that are generally present in low incidence, namely, monocytes, basophils, and eosinophils, are less well correlated. The microscopic band cell count provides the greatest test efficiency in the diagnosis of infection. None of the unique parameters generated by the H*1 differential analyzer proved to have neither a test efficiency nor a diagnostic index greater than that of the absolute WBC count in the diagnosis of infection. The 'left shift' in the leukocyte differential count as detected by the H*1 relates poorly to the presence of band neutrophils in the specimen. It is concluded that the state-of-the-art automated leukocyte differential count can dramatically reduce work-load, but offers no advantage over the traditional differential WBC count in the diagnosis of infectious disease. Its potential value in the diagnosis of other conditions, particularly hematologic diseases, and in the sequential monitoring of infections in individual patients were not addressed by the present study.

UR - http://www.scopus.com/inward/record.url?scp=0023160877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023160877&partnerID=8YFLogxK

M3 - Article

C2 - 3579507

AN - SCOPUS:0023160877

VL - 111

SP - 521

EP - 524

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 6

ER -