The great imitator revisited

The spectrum of atypical cutaneous manifestations of secondary syphilis

Yevgeniy Balagula, Peter L. Mattei, Oliver J. Wisco, Gulsun Erdag, Anna L. Chien

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Syphilis is a well-known sexually transmitted infection infamous for its protean cutaneous manifestations. Over the last decade, the rate of infection in the USA has risen, particularly among human immunodeficiency virus (HIV)-infected individuals and certain ethnic groups. Although the primary chancre developing at the site of inoculation usually has typical and well-characterized features, cutaneous manifestations of secondary syphilis span a wide spectrum and mimic those of other dermatoses. This may be particularly evident in patients with HIV. Such deviations from the expected typical papulosquamous eruption may present a diagnostic challenge and delay diagnosis and therapy. Given the increasing incidence of syphilis among the immunosuppressed patient population, recognition of atypical cutaneous manifestations is critical for adequate management. We review a range of cutaneous manifestations of secondary syphilis and the skin diseases it may mimic.

Original languageEnglish (US)
Pages (from-to)1434-1441
Number of pages8
JournalInternational Journal of Dermatology
Volume53
Issue number12
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

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Skin Manifestations
Syphilis
Skin Diseases
Chancre
HIV
Sexually Transmitted Diseases
Ethnic Groups
Secondary syphilis
Incidence
Infection
Population

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

The great imitator revisited : The spectrum of atypical cutaneous manifestations of secondary syphilis. / Balagula, Yevgeniy; Mattei, Peter L.; Wisco, Oliver J.; Erdag, Gulsun; Chien, Anna L.

In: International Journal of Dermatology, Vol. 53, No. 12, 01.12.2014, p. 1434-1441.

Research output: Contribution to journalArticle

Balagula, Yevgeniy ; Mattei, Peter L. ; Wisco, Oliver J. ; Erdag, Gulsun ; Chien, Anna L. / The great imitator revisited : The spectrum of atypical cutaneous manifestations of secondary syphilis. In: International Journal of Dermatology. 2014 ; Vol. 53, No. 12. pp. 1434-1441.
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