The GluR2 (GluR-B) hypothesis

Ca2+-permeable AMPA receptors in neurological disorders

Domenico E. Pellegrini-Giampietro, Jan A. Gorter, Michael V. L. Bennett, R. Suzanne Zukin

Research output: Contribution to journalArticle

435 Citations (Scopus)

Abstract

The abnormal influx of Ca2+ through glutamate receptor channels is thought to contribute to the loss of neurons associated with a number of brain disorders. Until recently, the NMDA receptor was the only glutamate receptor known to be Ca2+-permeable. It is now well established that AMPA receptors exist not only in Ca2+-impermeable but also in Ca2+-permeable forms. AMPA receptors are encoded by four genes designated gluRl (gluR-A) through gluR4 (gluR-D). The presence of the gluR2 subunit renders heteromeric AMPA receptor assemblies Ca2+-impermeable. Recent studies involving animal models of transient forebrain ischemia and epilepsy show that gluR2 mRNA is downregulated in vulnerable neurons. These observations suggest that downregulation of gluR2 gene expression may serve as a 'molecular switch' leading to the formation of Ca2+-permeable AMPA receptors and enhanced toxicity of endogenous glutamate following a neurological insult.

Original languageEnglish (US)
Pages (from-to)464-470
Number of pages7
JournalTrends in Neurosciences
Volume20
Issue number10
DOIs
StatePublished - Oct 1 1997

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AMPA Receptors
Nervous System Diseases
Glutamate Receptors
Down-Regulation
Neurons
Brain Diseases
Prosencephalon
N-Methyl-D-Aspartate Receptors
Glutamic Acid
Epilepsy
Ischemia
Animal Models
Gene Expression
Messenger RNA
glutamate receptor type B
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The GluR2 (GluR-B) hypothesis : Ca2+-permeable AMPA receptors in neurological disorders. / Pellegrini-Giampietro, Domenico E.; Gorter, Jan A.; Bennett, Michael V. L.; Zukin, R. Suzanne.

In: Trends in Neurosciences, Vol. 20, No. 10, 01.10.1997, p. 464-470.

Research output: Contribution to journalArticle

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