The genetic susceptibility to Graves' disease

Yaron Tomer, T. F. Davies

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Graves' disease (GD) develops as a result of a complex interaction between genetic susceptibility genes and likely environmental factors. Most epidemiological data support an important genetic contribution to the development of GD. The concordance rate of GD in monozygotic twins is 30-60% and in dizygotic twins 3-9%, and thyroid autoantibodies have been reported in up to 50% of the siblings of patients with GD. For many years now, HLA studies have consistently shown an increased frequency of HLA-DR3 in Caucasian patients with GD; but with only a risk ratio of 3-5. However, recent advances in human genome mapping techniques have enabled the study of many other candidate genes. Of these additional, non-HLA genes, only CTLA-4 has been consistently found to be associated with GD. Using a linkage based approach which only detects highly significant susceptibility genes we have recently reported preliminary results which demonstrated that a marker located ~ 25 cM from the TSH receptor gene on chromosome 14q31 is linked to GD and in the same vicinity as the IDDM-11 locus. Such results, if confirmed, may signal the presence of a gene family related to endocrine autoimmunity on chromosome 14q31.

Original languageEnglish (US)
Pages (from-to)431-450
Number of pages20
JournalBailliere's Clinical Endocrinology and Metabolism
Volume11
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Graves Disease
Genetic Predisposition to Disease
Genes
Chromosomes
Diseases in Twins
HLA-DR3 Antigen
Dizygotic Twins
Thyrotropin Receptors
Monozygotic Twins
Chromosome Mapping
Human Genome
Autoimmunity
Type 1 Diabetes Mellitus
Autoantibodies
Siblings
Thyroid Gland
Odds Ratio

Keywords

  • Association
  • Autoimmunity
  • Genes
  • Graves' disease
  • HLA
  • Linkage
  • Thyroid
  • TSH receptor

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

The genetic susceptibility to Graves' disease. / Tomer, Yaron; Davies, T. F.

In: Bailliere's Clinical Endocrinology and Metabolism, Vol. 11, No. 3, 1997, p. 431-450.

Research output: Contribution to journalArticle

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