The generation and propagation of the human alpha rhythm

Milan Halgren, István Ulbert, Hélène Bastuji, Dániel Fabó, Lorand Eross, Marc Rey, Orrin Devinsky, Werner K. Doyle, Rachel Mak-McCully, Eric Halgren, Lucia Wittner, Patrick Chauvel, Gary Heit, Emad Eskandar, Arnold Mandell, Sydney S. Cash

Research output: Contribution to journalArticle

Abstract

The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology is poorly understood. In this study, we used microelectrodes and macroelectrodes in surgical epilepsy patients to measure the intracortical and thalamic generators of the alpha rhythm during quiet wakefulness. We first found that alpha in both visual and somatosensory cortex propagates from higher-order to lower-order areas. In posterior cortex, alpha propagates from higher-order anterosuperior areas toward the occipital pole, whereas alpha in somatosensory cortex propagates from associative regions toward primary cortex. Several analyses suggest that this cortical alpha leads pulvinar alpha, complicating prevailing theories of a thalamic pacemaker. Finally, alpha is dominated by currents and firing in supragranular cortical layers. Together, these results suggest that the alpha rhythm likely reflects short-range supragranular feedback, which propagates from higher- to lower-order cortex and cortex to thalamus. These physiological insights suggest how alpha could mediate feedback throughout the thalamocortical system.

Original languageEnglish (US)
Pages (from-to)23772-23782
Number of pages11
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number47
DOIs
StatePublished - Jan 1 2019

Fingerprint

Alpha Rhythm
Somatosensory Cortex
Pulvinar
Wakefulness
Microelectrodes
Visual Cortex
Thalamus
Cognition
Epilepsy
Brain

Keywords

  • Alpha
  • Intracranial EEG
  • Laminar
  • Oscillations
  • Thalamocortical

ASJC Scopus subject areas

  • General

Cite this

Halgren, M., Ulbert, I., Bastuji, H., Fabó, D., Eross, L., Rey, M., ... Cash, S. S. (2019). The generation and propagation of the human alpha rhythm. Proceedings of the National Academy of Sciences of the United States of America, 116(47), 23772-23782. https://doi.org/10.1073/pnas.1913092116

The generation and propagation of the human alpha rhythm. / Halgren, Milan; Ulbert, István; Bastuji, Hélène; Fabó, Dániel; Eross, Lorand; Rey, Marc; Devinsky, Orrin; Doyle, Werner K.; Mak-McCully, Rachel; Halgren, Eric; Wittner, Lucia; Chauvel, Patrick; Heit, Gary; Eskandar, Emad; Mandell, Arnold; Cash, Sydney S.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 47, 01.01.2019, p. 23772-23782.

Research output: Contribution to journalArticle

Halgren, M, Ulbert, I, Bastuji, H, Fabó, D, Eross, L, Rey, M, Devinsky, O, Doyle, WK, Mak-McCully, R, Halgren, E, Wittner, L, Chauvel, P, Heit, G, Eskandar, E, Mandell, A & Cash, SS 2019, 'The generation and propagation of the human alpha rhythm', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 47, pp. 23772-23782. https://doi.org/10.1073/pnas.1913092116
Halgren, Milan ; Ulbert, István ; Bastuji, Hélène ; Fabó, Dániel ; Eross, Lorand ; Rey, Marc ; Devinsky, Orrin ; Doyle, Werner K. ; Mak-McCully, Rachel ; Halgren, Eric ; Wittner, Lucia ; Chauvel, Patrick ; Heit, Gary ; Eskandar, Emad ; Mandell, Arnold ; Cash, Sydney S. / The generation and propagation of the human alpha rhythm. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 47. pp. 23772-23782.
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