The G protein connection: molecular basis of membrane association

Allen M. Spiegel; Peter S. Backlund; James E. Butrynski; Teresa L.Z. Jones; William F. Simonds

doi:10.1016/0968-0004(91)90139-M

The G protein connection: molecular basis of membrane association

Allen M. Spiegel, Peter S. Backlund, James E. Butrynski, Teresa L.Z. Jones, William F. Simonds

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

Original language	English (US)
Pages (from-to)	338-341
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	16
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(91)90139-M
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0968-0004(91)90139-M

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title = "The G protein connection: molecular basis of membrane association",

abstract = "Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.",

author = "Spiegel, {Allen M.} and Backlund, {Peter S.} and Butrynski, {James E.} and Jones, {Teresa L.Z.} and Simonds, {William F.}",

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AU - Backlund, Peter S.

AU - Butrynski, James E.

AU - Jones, Teresa L.Z.

AU - Simonds, William F.

PY - 1991

Y1 - 1991

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AB - Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

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JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

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The G protein connection: molecular basis of membrane association

Abstract

ASJC Scopus subject areas

UN SDGs

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