The G protein connection: molecular basis of membrane association

Allen M. Spiegel, Peter S. Backlund, James E. Butrynski, Teresa L Z Jones, William F. Simonds

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalTrends in Biochemical Sciences
Volume16
Issue numberC
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

GTP-Binding Proteins
Prenylation
Membranes
Heterotrimeric GTP-Binding Proteins
Acquired Immunodeficiency Syndrome
Lipids
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Biochemistry

Cite this

The G protein connection : molecular basis of membrane association. / Spiegel, Allen M.; Backlund, Peter S.; Butrynski, James E.; Jones, Teresa L Z; Simonds, William F.

In: Trends in Biochemical Sciences, Vol. 16, No. C, 1991, p. 338-341.

Research output: Contribution to journalArticle

Spiegel, Allen M. ; Backlund, Peter S. ; Butrynski, James E. ; Jones, Teresa L Z ; Simonds, William F. / The G protein connection : molecular basis of membrane association. In: Trends in Biochemical Sciences. 1991 ; Vol. 16, No. C. pp. 338-341.
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