The future of GI and liver research: Editorial perspectives III. JNK/AP-1 regulation of hepatocyte death

Mark J. Czaja

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Activation of the JNK/activator protein-1 (AP-1)-signaling pathway is a common mediator of hepatocyte death from a variety of stimuli. Although the mechanism by which JNK or AP-1 promotes death is unknown, it results when activation of this signaling pathway is unusually prolonged. Although JNK/AP-1 mediates TNF-induced cell death at or above the level of the mitochondria, the ability of JNK/AP-1 to promote death from necrosis as well as apoptosis suggests that JNK/AP-1 may induce death by several mechanisms. Recognition of JNK/AP-1 signaling as a critical promoter of hepatocyte death raises the possibility that the therapeutic manipulation of this pathway may be effective in the treatment of human liver disease.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume284
Issue number6 47-6
StatePublished - Jun 1 2003

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Transcription Factor AP-1
Hepatocytes
Liver
Research
Liver Diseases
Mitochondria
Cell Death
Necrosis
Apoptosis

Keywords

  • Apoptosis
  • C-Jun
  • Hepatocyte
  • Mitogen-activated protein kinase
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

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