Abstract
Activation of the JNK/activator protein-1 (AP-1)-signaling pathway is a common mediator of hepatocyte death from a variety of stimuli. Although the mechanism by which JNK or AP-1 promotes death is unknown, it results when activation of this signaling pathway is unusually prolonged. Although JNK/AP-1 mediates TNF-induced cell death at or above the level of the mitochondria, the ability of JNK/AP-1 to promote death from necrosis as well as apoptosis suggests that JNK/AP-1 may induce death by several mechanisms. Recognition of JNK/AP-1 signaling as a critical promoter of hepatocyte death raises the possibility that the therapeutic manipulation of this pathway may be effective in the treatment of human liver disease.
Original language | English (US) |
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Pages (from-to) | G875-G879 |
Journal | American Journal of Physiology - Gastrointestinal and Liver Physiology |
Volume | 284 |
Issue number | 6 47-6 |
DOIs | |
State | Published - Jun 1 2003 |
Keywords
- Apoptosis
- C-Jun
- Hepatocyte
- Mitogen-activated protein kinase
- Tumor necrosis factor
ASJC Scopus subject areas
- Physiology
- Hepatology
- Gastroenterology
- Physiology (medical)