The future of GI and liver research: Editorial perspectives III. JNK/AP-1 regulation of hepatocyte death

Mark J. Czaja

Research output: Contribution to journalReview article

110 Scopus citations

Abstract

Activation of the JNK/activator protein-1 (AP-1)-signaling pathway is a common mediator of hepatocyte death from a variety of stimuli. Although the mechanism by which JNK or AP-1 promotes death is unknown, it results when activation of this signaling pathway is unusually prolonged. Although JNK/AP-1 mediates TNF-induced cell death at or above the level of the mitochondria, the ability of JNK/AP-1 to promote death from necrosis as well as apoptosis suggests that JNK/AP-1 may induce death by several mechanisms. Recognition of JNK/AP-1 signaling as a critical promoter of hepatocyte death raises the possibility that the therapeutic manipulation of this pathway may be effective in the treatment of human liver disease.

Original languageEnglish (US)
Pages (from-to)G875-G879
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume284
Issue number6 47-6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Apoptosis
  • C-Jun
  • Hepatocyte
  • Mitogen-activated protein kinase
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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