TY - JOUR
T1 - The Fungal Cell Wall
T2 - Candida, Cryptococcus, and Aspergillus Species
AU - Garcia-Rubio, Rocio
AU - de Oliveira, Haroldo C.
AU - Rivera, Johanna
AU - Trevijano-Contador, Nuria
N1 - Publisher Copyright:
© Copyright © 2020 Garcia-Rubio, de Oliveira, Rivera and Trevijano-Contador.
PY - 2020/1/9
Y1 - 2020/1/9
N2 - The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The cell wall is a skeleton with high plasticity that protects the cell from different stresses, among which osmotic changes stand out. The cell wall allows interaction with the external environment since some of its proteins are adhesins and receptors. Since, some components have a high immunogenic capacity, certain wall components can drive the host’s immune response to promote fungus growth and dissemination. The cell wall is a characteristic structure of fungi and is composed mainly of glucans, chitin and glycoproteins. As the components of the fungal cell wall are not present in humans, this structure is an excellent target for antifungal therapy. In this article, we review recent data on the composition and synthesis, influence of the components of the cell wall in fungi-host interaction and the role as a target for the next generation of antifungal drugs in yeasts (Candida and Cryptococcus) and filamentous fungi (Aspergillus).
AB - The fungal cell wall is located outside the plasma membrane and is the cell compartment that mediates all the relationships of the cell with the environment. It protects the contents of the cell, gives rigidity and defines the cellular structure. The cell wall is a skeleton with high plasticity that protects the cell from different stresses, among which osmotic changes stand out. The cell wall allows interaction with the external environment since some of its proteins are adhesins and receptors. Since, some components have a high immunogenic capacity, certain wall components can drive the host’s immune response to promote fungus growth and dissemination. The cell wall is a characteristic structure of fungi and is composed mainly of glucans, chitin and glycoproteins. As the components of the fungal cell wall are not present in humans, this structure is an excellent target for antifungal therapy. In this article, we review recent data on the composition and synthesis, influence of the components of the cell wall in fungi-host interaction and the role as a target for the next generation of antifungal drugs in yeasts (Candida and Cryptococcus) and filamentous fungi (Aspergillus).
KW - Aspergillus
KW - Candida
KW - Cryptococcus
KW - cell wall
KW - composition
KW - synthesis
UR - http://www.scopus.com/inward/record.url?scp=85078290161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078290161&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2019.02993
DO - 10.3389/fmicb.2019.02993
M3 - Review article
AN - SCOPUS:85078290161
SN - 1664-302X
VL - 10
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 2993
ER -