The ferret as an animal model in cerebrovascular research

C. Scott Atkinson, Gary A. Press, Patrick Lyden, Barrett Katz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in vivo cerebral angiography and postmortem neurovascu-lar dissection of latex-injected specimens of adult ferrets. The great vessels include a cervical arterial trunk that gives rise to both carotid arteries. The anatomy of the cranial arteries is similar to that of rabbits. No carotid rete mirabile is present. There are no intracranial anastomoses between the external and internal carotid systems. We present in vivo cerebral angiograms with pathologic correlation that demonstrate that ferrets may provide the same anatomic advantages as a rabbit model for the experimental study of cerebrovascular disease, with the additional advantage of a long extracranial cervical segment of the carotid artery, affording easier access to the intracranial vasculature.

Original languageEnglish (US)
Pages (from-to)1085-1088
Number of pages4
JournalStroke
Volume20
Issue number8
StatePublished - 1989
Externally publishedYes

Fingerprint

Ferrets
Animal Models
Research
Carotid Arteries
Rabbits
Cerebrovascular Disorders
Cerebral Angiography
Latex
Nervous System
Dissection
Anatomy
Angiography
Theoretical Models
Arteries
Stroke

Keywords

  • Anatomy
  • Angiography
  • Animal models
  • Ferrets

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Atkinson, C. S., Press, G. A., Lyden, P., & Katz, B. (1989). The ferret as an animal model in cerebrovascular research. Stroke, 20(8), 1085-1088.

The ferret as an animal model in cerebrovascular research. / Atkinson, C. Scott; Press, Gary A.; Lyden, Patrick; Katz, Barrett.

In: Stroke, Vol. 20, No. 8, 1989, p. 1085-1088.

Research output: Contribution to journalArticle

Atkinson, CS, Press, GA, Lyden, P & Katz, B 1989, 'The ferret as an animal model in cerebrovascular research', Stroke, vol. 20, no. 8, pp. 1085-1088.
Atkinson CS, Press GA, Lyden P, Katz B. The ferret as an animal model in cerebrovascular research. Stroke. 1989;20(8):1085-1088.
Atkinson, C. Scott ; Press, Gary A. ; Lyden, Patrick ; Katz, Barrett. / The ferret as an animal model in cerebrovascular research. In: Stroke. 1989 ; Vol. 20, No. 8. pp. 1085-1088.
@article{4d1b2ec72a584819b53f330edf2d3735,
title = "The ferret as an animal model in cerebrovascular research",
abstract = "Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in vivo cerebral angiography and postmortem neurovascu-lar dissection of latex-injected specimens of adult ferrets. The great vessels include a cervical arterial trunk that gives rise to both carotid arteries. The anatomy of the cranial arteries is similar to that of rabbits. No carotid rete mirabile is present. There are no intracranial anastomoses between the external and internal carotid systems. We present in vivo cerebral angiograms with pathologic correlation that demonstrate that ferrets may provide the same anatomic advantages as a rabbit model for the experimental study of cerebrovascular disease, with the additional advantage of a long extracranial cervical segment of the carotid artery, affording easier access to the intracranial vasculature.",
keywords = "Anatomy, Angiography, Animal models, Ferrets",
author = "Atkinson, {C. Scott} and Press, {Gary A.} and Patrick Lyden and Barrett Katz",
year = "1989",
language = "English (US)",
volume = "20",
pages = "1085--1088",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - The ferret as an animal model in cerebrovascular research

AU - Atkinson, C. Scott

AU - Press, Gary A.

AU - Lyden, Patrick

AU - Katz, Barrett

PY - 1989

Y1 - 1989

N2 - Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in vivo cerebral angiography and postmortem neurovascu-lar dissection of latex-injected specimens of adult ferrets. The great vessels include a cervical arterial trunk that gives rise to both carotid arteries. The anatomy of the cranial arteries is similar to that of rabbits. No carotid rete mirabile is present. There are no intracranial anastomoses between the external and internal carotid systems. We present in vivo cerebral angiograms with pathologic correlation that demonstrate that ferrets may provide the same anatomic advantages as a rabbit model for the experimental study of cerebrovascular disease, with the additional advantage of a long extracranial cervical segment of the carotid artery, affording easier access to the intracranial vasculature.

AB - Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in vivo cerebral angiography and postmortem neurovascu-lar dissection of latex-injected specimens of adult ferrets. The great vessels include a cervical arterial trunk that gives rise to both carotid arteries. The anatomy of the cranial arteries is similar to that of rabbits. No carotid rete mirabile is present. There are no intracranial anastomoses between the external and internal carotid systems. We present in vivo cerebral angiograms with pathologic correlation that demonstrate that ferrets may provide the same anatomic advantages as a rabbit model for the experimental study of cerebrovascular disease, with the additional advantage of a long extracranial cervical segment of the carotid artery, affording easier access to the intracranial vasculature.

KW - Anatomy

KW - Angiography

KW - Animal models

KW - Ferrets

UR - http://www.scopus.com/inward/record.url?scp=0024316639&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024316639&partnerID=8YFLogxK

M3 - Article

C2 - 2756540

AN - SCOPUS:0024316639

VL - 20

SP - 1085

EP - 1088

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 8

ER -