TY - JOUR
T1 - The fate of the messenger is pre-determined
T2 - A new model for regulation of gene expression
AU - Haimovich, Gal
AU - Choder, Mordechai
AU - Singer, Robert H.
AU - Trcek, Tatjana
N1 - Funding Information:
We would like to thank Dr. Oliver Mühlemann for his help with the writing of the NMD-dependent mRNA surveillance section. This review was supported by the Gruss Lipper family postdoctoral fellowship awarded to GH and the HHMI fellowship of The Jane Coffin Childs Memorial Fund for Medical Research awarded to TTP. Work in MC laboratory is supported by grants from “ Israel Science Foundation ”, “ US–Israel Binational Foundation ” and by the Israeli Ministry of Health . Work in RHS lab is supported by NIHGM57071.
PY - 2013/6
Y1 - 2013/6
N2 - Recent years have seen a rise in publications demonstrating coupling between transcription and mRNA decay. This coupling most often accompanies cellular processes that involve transitions in gene expression patterns, for example during mitotic division and cellular differentiation and in response to cellular stress. Transcription can affect the mRNA fate by multiple mechanisms. The most novel finding is the process of co-transcriptional imprinting of mRNAs with proteins, which in turn regulate cytoplasmic mRNA stability. Transcription therefore is not only a catalyst of mRNA synthesis but also provides a platform that enables imprinting, which coordinates between transcription and mRNA decay. Here we present an overview of the literature, which provides the evidence of coupling between transcription and decay, review the mechanisms and regulators by which the two processes are coupled, discuss why such coupling is beneficial and present a new model for regulation of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms.
AB - Recent years have seen a rise in publications demonstrating coupling between transcription and mRNA decay. This coupling most often accompanies cellular processes that involve transitions in gene expression patterns, for example during mitotic division and cellular differentiation and in response to cellular stress. Transcription can affect the mRNA fate by multiple mechanisms. The most novel finding is the process of co-transcriptional imprinting of mRNAs with proteins, which in turn regulate cytoplasmic mRNA stability. Transcription therefore is not only a catalyst of mRNA synthesis but also provides a platform that enables imprinting, which coordinates between transcription and mRNA decay. Here we present an overview of the literature, which provides the evidence of coupling between transcription and decay, review the mechanisms and regulators by which the two processes are coupled, discuss why such coupling is beneficial and present a new model for regulation of gene expression. This article is part of a Special Issue entitled: RNA Decay mechanisms.
KW - CCR4-NOT
KW - MRNA decay
KW - MRNA imprinting
KW - Poly(A) binding protein
KW - Rpb4/7
KW - Transcription
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U2 - 10.1016/j.bbagrm.2013.01.004
DO - 10.1016/j.bbagrm.2013.01.004
M3 - Review article
C2 - 23337853
AN - SCOPUS:84877834690
SN - 1874-9399
VL - 1829
SP - 643
EP - 653
JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
IS - 6-7
ER -