The evolving role for re-irradiation in the management of recurrent grade 4 glioma

Steven P. Howard, Andra Krauze, Mike D. Chan, Christina Tsien, Wolfgang A. Tome

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although significant gains have been realized in the management of grade 4 glioma, the majority of these patients will ultimately suffer local recurrence within the prior field of treatment. Clearly, novel local treatment strategies are required to improve patient outcomes. Concerns of toxicity have limited enthusiasm for the utilization of re-irradiation as a treatment option. However, using modern imaging technology and precision radiotherapy delivery techniques re-irradiation has proven a feasible option achieving both a palliative benefit and prolongation of survival with low toxicity rates. The evolution of re-irradiation as a treatment modality for recurrent grade 4 glioma is reviewed. In addition, potential targeted radiosensitizers to be used in conjunction with re-irradiation are also discussed.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Neuro-Oncology
DOIs
StateAccepted/In press - Apr 6 2017

Fingerprint

Glioma
Therapeutics
Radiotherapy
Technology
Recurrence
Survival
Re-Irradiation

Keywords

  • Central nervous system
  • Radiosensitizers
  • Re-irradiation
  • Recurrent grade 4 glioma

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

The evolving role for re-irradiation in the management of recurrent grade 4 glioma. / Howard, Steven P.; Krauze, Andra; Chan, Mike D.; Tsien, Christina; Tome, Wolfgang A.

In: Journal of Neuro-Oncology, 06.04.2017, p. 1-8.

Research output: Contribution to journalArticle

Howard, Steven P. ; Krauze, Andra ; Chan, Mike D. ; Tsien, Christina ; Tome, Wolfgang A. / The evolving role for re-irradiation in the management of recurrent grade 4 glioma. In: Journal of Neuro-Oncology. 2017 ; pp. 1-8.
@article{505f01efcf8b49f080301fb9a76a739a,
title = "The evolving role for re-irradiation in the management of recurrent grade 4 glioma",
abstract = "Although significant gains have been realized in the management of grade 4 glioma, the majority of these patients will ultimately suffer local recurrence within the prior field of treatment. Clearly, novel local treatment strategies are required to improve patient outcomes. Concerns of toxicity have limited enthusiasm for the utilization of re-irradiation as a treatment option. However, using modern imaging technology and precision radiotherapy delivery techniques re-irradiation has proven a feasible option achieving both a palliative benefit and prolongation of survival with low toxicity rates. The evolution of re-irradiation as a treatment modality for recurrent grade 4 glioma is reviewed. In addition, potential targeted radiosensitizers to be used in conjunction with re-irradiation are also discussed.",
keywords = "Central nervous system, Radiosensitizers, Re-irradiation, Recurrent grade 4 glioma",
author = "Howard, {Steven P.} and Andra Krauze and Chan, {Mike D.} and Christina Tsien and Tome, {Wolfgang A.}",
year = "2017",
month = "4",
day = "6",
doi = "10.1007/s11060-017-2392-1",
language = "English (US)",
pages = "1--8",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",

}

TY - JOUR

T1 - The evolving role for re-irradiation in the management of recurrent grade 4 glioma

AU - Howard, Steven P.

AU - Krauze, Andra

AU - Chan, Mike D.

AU - Tsien, Christina

AU - Tome, Wolfgang A.

PY - 2017/4/6

Y1 - 2017/4/6

N2 - Although significant gains have been realized in the management of grade 4 glioma, the majority of these patients will ultimately suffer local recurrence within the prior field of treatment. Clearly, novel local treatment strategies are required to improve patient outcomes. Concerns of toxicity have limited enthusiasm for the utilization of re-irradiation as a treatment option. However, using modern imaging technology and precision radiotherapy delivery techniques re-irradiation has proven a feasible option achieving both a palliative benefit and prolongation of survival with low toxicity rates. The evolution of re-irradiation as a treatment modality for recurrent grade 4 glioma is reviewed. In addition, potential targeted radiosensitizers to be used in conjunction with re-irradiation are also discussed.

AB - Although significant gains have been realized in the management of grade 4 glioma, the majority of these patients will ultimately suffer local recurrence within the prior field of treatment. Clearly, novel local treatment strategies are required to improve patient outcomes. Concerns of toxicity have limited enthusiasm for the utilization of re-irradiation as a treatment option. However, using modern imaging technology and precision radiotherapy delivery techniques re-irradiation has proven a feasible option achieving both a palliative benefit and prolongation of survival with low toxicity rates. The evolution of re-irradiation as a treatment modality for recurrent grade 4 glioma is reviewed. In addition, potential targeted radiosensitizers to be used in conjunction with re-irradiation are also discussed.

KW - Central nervous system

KW - Radiosensitizers

KW - Re-irradiation

KW - Recurrent grade 4 glioma

UR - http://www.scopus.com/inward/record.url?scp=85017119351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017119351&partnerID=8YFLogxK

U2 - 10.1007/s11060-017-2392-1

DO - 10.1007/s11060-017-2392-1

M3 - Article

C2 - 28386661

AN - SCOPUS:85017119351

SP - 1

EP - 8

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

ER -