The evolving definition of carcinogenic human papillomavirus

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Thirteen human papillomavirus (HPV) genotypes have been judged to be carcinogenic or probably carcinogenic, and the cause of virtually all cervical cancer worldwide. Other HPV genotypes could possibly be involved. Although the inclusion of possibly carcinogenic HPV genotypes may hurt test specificity, it may indirectly increase the reassurance following a negative HPV test (i.e. the negative predictive value of an HPV test for cervical precancer and cancer). The future of cervical cancer screening in low-resource setting, however, may include once-in-a-lifetime, low-cost and rapid HPV testing. However, the tradeoff of more false positives for greater reassurance may not be acceptable if the local infrastructure cannot manage the screen positives. Now is the time for the community of scientists, doctors, and public health advocates to use the data presented at the 100th International Agency for Research on Cancer monograph meeting to rationally decide the target HPV genotypes for the next generation of HPV tests for use in high-resource and low-resource settings. The implications of including possibly HPV genotypes on HPV test performance, also for guidance on the use of these tests for cervical cancer prevention programs, are discussed.

Original languageEnglish (US)
Article number7
JournalInfectious Agents and Cancer
Volume4
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

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Uterine Cervical Neoplasms
Genotype
International Agencies
Early Detection of Cancer
Public Health
Costs and Cost Analysis
Research
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Epidemiology
  • Infectious Diseases
  • Oncology

Cite this

The evolving definition of carcinogenic human papillomavirus. / Castle, Philip E.

In: Infectious Agents and Cancer, Vol. 4, No. 1, 7, 2009.

Research output: Contribution to journalArticle

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