TY - JOUR
T1 - The evolution of interference
T2 - Reduction of recombination among three loci
AU - Goldstein, David B.
AU - Bergman, Aviv
AU - Feldman, Marcus W.
PY - 1993/10
Y1 - 1993/10
N2 - Crossover events along chromosomes do not occur independently, but influence the probably of other nearby events. The most common interaction between nearby crossover events is inhibitory: a crossover event tends to reduce the probability of other such events nearby, and this is called positive interference. A crossover event may increase the probability of events nearby, and this rare phenomenon is called negative interference. In this paper, we use numerical methods to investigate how interference among three loci would evolve if it were under the genetic control of a fourth, selectively neutral locus. We first discuss the effect of interference on the overall rate of recombination among the three loci, and then show that, under a variety of conditions, interference evolves in the same way as would be predicted based upon its effect on the overall rate of recombination. That is, the overall rate evolves in the same direction as would the rate at a locus that controls recombinalion between two loci directly. We then check for the existence of viability-analogous Hardy-Weinberg equilibria in the four-locus model of interference modification.
AB - Crossover events along chromosomes do not occur independently, but influence the probably of other nearby events. The most common interaction between nearby crossover events is inhibitory: a crossover event tends to reduce the probability of other such events nearby, and this is called positive interference. A crossover event may increase the probability of events nearby, and this rare phenomenon is called negative interference. In this paper, we use numerical methods to investigate how interference among three loci would evolve if it were under the genetic control of a fourth, selectively neutral locus. We first discuss the effect of interference on the overall rate of recombination among the three loci, and then show that, under a variety of conditions, interference evolves in the same way as would be predicted based upon its effect on the overall rate of recombination. That is, the overall rate evolves in the same direction as would the rate at a locus that controls recombinalion between two loci directly. We then check for the existence of viability-analogous Hardy-Weinberg equilibria in the four-locus model of interference modification.
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U2 - 10.1006/tpbi.1993.1028
DO - 10.1006/tpbi.1993.1028
M3 - Article
C2 - 8248888
AN - SCOPUS:0027686805
SN - 0040-5809
VL - 44
SP - 246
EP - 259
JO - Theoretical Population Biology
JF - Theoretical Population Biology
IS - 2
ER -