The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

Xiangming Xing, Shao Chun Wang, Weiya Xia, Yiyu Zou, Ruping Shao, Ka Yin Kwong, Zhenming Yu, Su Zhang, Susan Miller, Leaf Huang, Mien Chie Hung

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER- 2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu- overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalNature Medicine
Volume6
Issue number2
DOIs
StatePublished - Feb 2000
Externally publishedYes

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Carcinogenesis
Genes
DNA sequences
DNA-Binding Proteins
Cell growth
Tumors
Neoplasms
Proteins
Cells
Growth and Development
Down-Regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Xing, X., Wang, S. C., Xia, W., Zou, Y., Shao, R., Kwong, K. Y., ... Hung, M. C. (2000). The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine, 6(2), 189-195. https://doi.org/10.1038/72294

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. / Xing, Xiangming; Wang, Shao Chun; Xia, Weiya; Zou, Yiyu; Shao, Ruping; Kwong, Ka Yin; Yu, Zhenming; Zhang, Su; Miller, Susan; Huang, Leaf; Hung, Mien Chie.

In: Nature Medicine, Vol. 6, No. 2, 02.2000, p. 189-195.

Research output: Contribution to journalArticle

Xing, X, Wang, SC, Xia, W, Zou, Y, Shao, R, Kwong, KY, Yu, Z, Zhang, S, Miller, S, Huang, L & Hung, MC 2000, 'The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis', Nature Medicine, vol. 6, no. 2, pp. 189-195. https://doi.org/10.1038/72294
Xing, Xiangming ; Wang, Shao Chun ; Xia, Weiya ; Zou, Yiyu ; Shao, Ruping ; Kwong, Ka Yin ; Yu, Zhenming ; Zhang, Su ; Miller, Susan ; Huang, Leaf ; Hung, Mien Chie. / The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. In: Nature Medicine. 2000 ; Vol. 6, No. 2. pp. 189-195.
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