The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

Xiangming Xing, Shao Chun Wang, Weiya Xia, Yiyu Zou, Ruping Shao, Ka Yin Kwong, Zhenming Yu, Su Zhang, Susan Miller, Leaf Huang, Mien Chie Hung

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER- 2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu- overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalNature Medicine
Volume6
Issue number2
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Xing, X., Wang, S. C., Xia, W., Zou, Y., Shao, R., Kwong, K. Y., Yu, Z., Zhang, S., Miller, S., Huang, L., & Hung, M. C. (2000). The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Medicine, 6(2), 189-195. https://doi.org/10.1038/72294